TAS2R43

Receptor ukusa tip 2 član 43

Identifikatori

TAS2R43; T2R43; T2R52

Vanjski ID

OMIM: 612668 HomoloGene: 128798 IUPHAR: GeneCards: TAS2R43 Gene

Ontologija gena
Molekularna funkcija	• aktivnost receptora ukusa
Celularna komponenta	• integralno sa membranom
Biološki proces	• signalni put G-protein spregnutog receptora

Ortolozi

Vrsta

Čovek

Miš

Entrez

259289

n/a

Ensembl

ENSG00000255374

n/a

UniProt

P59537

n/a

RefSeq (mRNA)

NM_176884.2

n/a

RefSeq (protein)

NP_795365.2

n/a

Lokacija (UCSC)

Chr 12:
11.24 - 11.24 Mb

n/a

PubMed pretraga

[1]

n/a

Receptor ukusa tip 2 član 43 je protein koji je kod ljudi kodiran TAS2R43 genom.^[1]^[2]

Reference

^ Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W (2002). „The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides”. Nat Genet. 32 (3): 397—401. PMID 12379855. doi:10.1038/ng1014.
^ „Entrez Gene: TAS2R43 taste receptor, type 2, member 43”.

Literatura

Margolskee RF (2002). „Molecular mechanisms of bitter and sweet taste transduction.”. J. Biol. Chem. 277 (1): 1—4. PMID 11696554. doi:10.1074/jbc.R100054200.
Montmayeur JP, Matsunami H (2002). „Receptors for bitter and sweet taste.”. Curr. Opin. Neurobiol. 12 (4): 366—71. PMID 12139982. doi:10.1016/S0959-4388(02)00345-8.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899. CS1 одржавање: Експлицитна употреба et al. (веза)
Zhang Y; Hoon MA; Chandrashekar J; et al. (2003). „Coding of sweet, bitter, and umami tastes: different receptor cells sharing similar signaling pathways.”. Cell. 112 (3): 293—301. PMID 12581520. doi:10.1016/S0092-8674(03)00071-0. CS1 одржавање: Експлицитна употреба et al. (веза)
Conte C; Ebeling M; Marcuz A; et al. (2003). „Identification and characterization of human taste receptor genes belonging to the TAS2R family.”. Cytogenet. Genome Res. 98 (1): 45—53. PMID 12584440. doi:10.1159/000068546. CS1 одржавање: Експлицитна употреба et al. (веза)
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504. CS1 одржавање: Експлицитна употреба et al. (веза)
Fischer A, Gilad Y, Man O, Pääbo S (2005). „Evolution of bitter taste receptors in humans and apes.”. Mol. Biol. Evol. 22 (3): 432—6. PMID 15496549. doi:10.1093/molbev/msi027.
Kuhn C; Bufe B; Winnig M; et al. (2005). „Bitter taste receptors for saccharin and acesulfame K.”. J. Neurosci. 24 (45): 10260—5. PMID 15537898. doi:10.1523/JNEUROSCI.1225-04.2004. CS1 одржавање: Експлицитна употреба et al. (веза)
Go Y, Satta Y, Takenaka O, Takahata N (2006). „Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates.”. Genetics. 170 (1): 313—26. PMC 1449719 . PMID 15744053. doi:10.1534/genetics.104.037523.
Behrens M; Bartelt J; Reichling C; et al. (2006). „Members of RTP and REEP gene families influence functional bitter taste receptor expression.”. J. Biol. Chem. 281 (29): 20650—9. PMID 16720576. doi:10.1074/jbc.M513637200. CS1 одржавање: Експлицитна употреба et al. (веза)

Vidi još

Receptor ukusa

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)