Moždano specifični angiogenezni inhibitor 1

Identifikatori

BAI1; GDAIF

Vanjski ID

OMIM: 602682 MGI: 1933736 HomoloGene: 1287 IUPHAR: BAI1 GeneCards: BAI1 Gene

Ontologija gena
Molekularna funkcija	• aktivnost G-protein spregnutog receptora • proteinsko vezivanje
Celularna komponenta	• citoplazma • ćelijska membrana • integralno sa ćelijskom membranom • ćelijska površina
Biološki proces	• ćelijska adhezija • signalni put G-protein spregnutog receptora • prenos signala • neuropeptidni signalni put

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

575

107831

Ensembl

ENSG00000181790

ENSMUSG00000034730

UniProt

O14514

Q3UHD1

RefSeq (mRNA)

NM_001702.2

NM_174991.3

RefSeq (protein)

NP_001693.2

NP_778156.2

Lokacija (UCSC)

Chr 8:
143.53 - 143.63 Mb

Chr 15:
74.35 - 74.42 Mb

PubMed pretraga

[1]

[2]

Moždano specifični angiogenezni inhibitor 1 je protein koji je kod ljudi kodiran BAI1 genom.^[1]^[2] On je inhibitor angiogeneze i supresor rasta glioblastoma.^[2]

Angiogeneza je kontrolisana lokalnim balansom između stimulatora i inhibitora rasta novih krvnih sudova, i supresovana je pod normalnim fiziološkim uslovima. Angiogeneza je esencijalna za rast i metastazu čvrstih tumora. Da bi obezbedile snabdevanje krvi koji je neophodno za njihov rast, ćelije tumora su potentno angiogene i privlače nove krvne sudove usled povišene sekrecije induktivnih agenasa i umanjene produkcije endogenih negativnih regulatora. BAI1 sadrži najmanje jedano funkcionalno p53 mesto vezivanja unutar introna, i njegovo izražavanje može da bude indukovano p53 faktorom. Postoje dva druga gena moždano specifičnih angiogeneznih inhibitor, BAI2 i BAI3, koji zajedno sa BAI1 imaju slične tkivne karakteristike i strukture, međutim samo BAI1 je transkripciono regulisan p53 proteinom. BAI1 je član sekretinske receptorske familije.

Interakcije

Moždano specifični angiogenezni inhibitor 1 formira interakcije sa BAIAP3^[3] i MAGI1.^[4]

Reference

^ Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T (1998). „Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1)”. Cytogenet Cell Genet. 79 (1–2): 103—8. PMID 9533023. doi:10.1159/000134693.
^ ^а ^б „Entrez Gene: BAI1 brain-specific angiogenesis inhibitor 1”.
^ Shiratsuchi, T; Oda K; et al. (1998). „Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1”. Biochem. Biophys. Res. Commun. UNITED STATES. 251 (1): 158—65. ISSN 0006-291X. PMID 9790924. doi:10.1006/bbrc.1998.9408.
^ Shiratsuchi, T; Futamura M; et al. (1998). „Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1”. Biochem. Biophys. Res. Commun. UNITED STATES. 247 (3): 597—604. ISSN 0006-291X. PMID 9647739. doi:10.1006/bbrc.1998.8603.

Literatura

Van Meir EG; Polverini PJ; Chazin VR; et al. (1995). „Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells”. Nat. Genet. 8 (2): 171—6. PMID 7531056. doi:10.1038/ng1094-171.
Nishimori H; Shiratsuchi T; Urano T; et al. (1997). „A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis”. Oncogene. 15 (18): 2145—50. PMID 9393972. doi:10.1038/sj.onc.1201542.
Shiratsuchi T; Futamura M; Oda K; et al. (1998). „Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1”. Biochem. Biophys. Res. Commun. 247 (3): 597—604. PMID 9647739. doi:10.1006/bbrc.1998.8603.
Fukushima Y; Oshika Y; Tsuchida T; et al. (1998). „Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer”. Int. J. Oncol. 13 (5): 967—70. PMID 9772287.
Shiratsuchi T; Oda K; Nishimori H; et al. (1998). „Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1”. Biochem. Biophys. Res. Commun. 251 (1): 158—65. PMID 9790924. doi:10.1006/bbrc.1998.9408.
Oda K; Shiratsuchi T; Nishimori H; et al. (1999). „Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1”. Cytogenet. Cell Genet. 84 (1–2): 75—82. PMID 10343108. doi:10.1159/000015219.
Wu Y; Dowbenko D; Spencer S; et al. (2000). „Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase”. J. Biol. Chem. 275 (28): 21477—85. PMID 10748157. doi:10.1074/jbc.M909741199.
Koh JT; Lee ZH; Ahn KY; et al. (2001). „Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein”. Brain Res. Mol. Brain Res. 87 (2): 223—37. PMID 11245925. doi:10.1016/S0169-328X(01)00004-3.
Duda DG; Sunamura M; Lozonschi L; et al. (2002). „Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis”. Br. J. Cancer. 86 (3): 490—6. PMC 2375213 . PMID 11875720. doi:10.1038/sj.bjc.6600067.
Lim IA, Hall DD, Hell JW (2002). „Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102”. J. Biol. Chem. 277 (24): 21697—711. PMID 11937501. doi:10.1074/jbc.M112339200.
Mori K; Kanemura Y; Fujikawa H; et al. (2002). „Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells”. Neurosci. Res. 43 (1): 69—74. PMID 12074842. doi:10.1016/S0168-0102(02)00018-4.
Kaur B, Brat DJ, Calkins CC, Van Meir EG (2003). „Brain Angiogenesis Inhibitor 1 Is Differentially Expressed in Normal Brain and Glioblastoma Independently of p53 Expression”. Am. J. Pathol. 162 (1): 19—27. PMC 1851137 . PMID 12507886. doi:10.1016/S0002-9440(10)63794-7.
Adkins JN; Varnum SM; Auberry KJ; et al. (2003). „Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry”. Mol. Cell Proteomics. 1 (12): 947—55. PMID 12543931. doi:10.1074/mcp.M200066-MCP200.
Ota T; Suzuki Y; Nishikawa T; et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40—5. PMID 14702039. doi:10.1038/ng1285.
Koh JT; Kook H; Kee HJ; et al. (2004). „Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin”. Exp. Cell Res. 294 (1): 172—84. PMID 14980512. doi:10.1016/j.yexcr.2003.11.008.
Bjarnadóttir TK; Fredriksson R; Höglund PJ; et al. (2005). „The human and mouse repertoire of the adhesion family of G-protein-coupled receptors”. Genomics. 84 (1): 23—33. PMID 15203201. doi:10.1016/j.ygeno.2003.12.004.

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)