GPR37

G protein-spregnuti receptor 37

Identifikatori

GPR37; EDNRBL; PAELR; hET(B)R-LP

Vanjski ID

OMIM: 602583 MGI: 1313297 HomoloGene: 3875 IUPHAR: GPR37 GeneCards: GPR37 Gene

Ontologija gena
Molekularna funkcija	• aktivnost rodopsinu sličnog receptora • receptorska aktivnost • aktivnost purinergičkog nukleotidnog receptora, G-protein spregnutog
Celularna komponenta	• integralno sa ćelijskom membranom • membrana
Biološki proces	• prenos signala • signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

2861

14763

Ensembl

ENSG00000170775

ENSMUSG00000039904

UniProt

O15354

Q9QY42

RefSeq (mRNA)

NM_005302

NM_010338

RefSeq (protein)

NP_005293

NP_034468

Lokacija (UCSC)

Chr 7:
124.17 - 124.19 Mb

Chr 6:
25.62 - 25.64 Mb

PubMed pretraga

[1]

[2]

GPR37, G protein-spregnuti receptor 37, je protein koji je kod čoveka kodiran GPR37 genom.^[1]^[2]

Interakcije

Za GPR37 je pokazano da interaguje sa HSPA1A^[3] i parkin ligazom.^[3]^[4]

Reference

^ Marazziti D, Golini E, Gallo A, Lombardi MS, Matteoni R, Tocchini-Valentini GP (novembar 1997). „Cloning of GPR37, a gene located on chromosome 7 encoding a putative G-protein-coupled peptide receptor, from a human frontal brain EST library”. Genomics. 45 (1): 68—77. PMID 9339362. doi:10.1006/geno.1997.4900.
^ „Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)”.
^ ^а ^б Imai, Yuzuru; Soda Mariko; et al. (jul 2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity”. Mol. Cell. United States. 10 (1): 55—67. ISSN 1097-2765. PMID 12150907. doi:10.1016/S1097-2765(02)00583-X.
^ Imai, Y; Soda M; et al. (jun 2001). „An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin”. Cell. United States. 105 (7): 891—902. ISSN 0092-8674. PMID 11439185. doi:10.1016/S0092-8674(01)00407-X.

Literatura

Zeng Z, Su K, Kyaw H, Li Y (1997). „A novel endothelin receptor type-B-like gene enriched in the brain.”. Biochem. Biophys. Res. Commun. 233 (2): 559—67. PMID 9144577. doi:10.1006/bbrc.1997.6408.
Donohue PJ; Shapira H; Mantey SA; et al. (1998). „A human gene encodes a putative G protein-coupled receptor highly expressed in the central nervous system.”. Brain Res. Mol. Brain Res. 54 (1): 152—60. PMID 9526070. doi:10.1016/S0169-328X(97)00336-7.
Imai Y; Soda M; Inoue H; et al. (2001). „An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin.”. Cell. 105 (7): 891—902. PMID 11439185. doi:10.1016/S0092-8674(01)00407-X.
Imai Y; Soda M; Hatakeyama S; et al. (2002). „CHIP is associated with Parkin, a gene responsible for familial Parkinson's disease, and enhances its ubiquitin ligase activity.”. Mol. Cell. 10 (1): 55—67. PMID 12150907. doi:10.1016/S1097-2765(02)00583-X.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Yang Y; Nishimura I; Imai Y; et al. (2003). „Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila.”. Neuron. 37 (6): 911—24. PMID 12670421. doi:10.1016/S0896-6273(03)00143-0.
Scherer SW; Cheung J; MacDonald JR; et al. (2003). „Human chromosome 7: DNA sequence and biology.”. Science. 300 (5620): 767—72. PMC 2882961 . PMID 12690205. doi:10.1126/science.1083423.
Hillier LW; Fulton RS; Fulton LA; et al. (2003). „The DNA sequence of human chromosome 7.”. Nature. 424 (6945): 157—64. PMID 12853948. doi:10.1038/nature01782.
Imai Y; Soda M; Murakami T; et al. (2004). „A product of the human gene adjacent to parkin is a component of Lewy bodies and suppresses Pael receptor-induced cell death.”. J. Biol. Chem. 278 (51): 51901—10. PMID 14532270. doi:10.1074/jbc.M309655200.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Kubota K; Niinuma Y; Kaneko M; et al. (2006). „Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress.”. J. Neurochem. 97 (5): 1259—68. PMID 16539653. doi:10.1111/j.1471-4159.2006.03782.x.
Omura T; Kaneko M; Okuma Y; et al. (2007). „A ubiquitin ligase HRD1 promotes the degradation of Pael receptor, a substrate of Parkin.”. J. Neurochem. 99 (6): 1456—69. PMID 17059562. doi:10.1111/j.1471-4159.2006.04155.x.

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)