Receptor paratiroidnog hormona 2

Identifikatori

PTH2R; PTHR2

Vanjski ID

OMIM: 601469 MGI: 2180917 HomoloGene: 3701 IUPHAR: PTH2 GeneCards: PTH2R Gene

Ontologija gena
Molekularna funkcija	• aktivnost paratiroidnog hormonskog receptora
Celularna komponenta	• ćelijska membrana • integralno sa ćelijskom membranom
Biološki proces	• signalni put G-protein spregnutog receptora

Pregled RNK izražavanja

podaci

Ortolozi

Vrsta

Čovek

Miš

Entrez

5746

213527

Ensembl

ENSG00000144407

ENSMUSG00000025946

UniProt

P49190

Q91V95

RefSeq (mRNA)

NM_005048.2

NM_139270.2

RefSeq (protein)

NP_005039.1

NP_644676.1

Lokacija (UCSC)

Chr 2:
209.22 - 209.72 Mb

Chr 1:
65.33 - 65.44 Mb

PubMed pretraga

[1]

[2]

Parathyroid hormone 2 receptor je protein koji je kod ljudi kodiran PTH2R genom^[1]

Funkcija

Ovaj protein je član familije 2 G protein spregnutih receptora. On je receptor za paratiroidni hormon (PTH). Ovaj receptor je selektiviji u prepoznavanju liganda i ima specifičniju tkivnu distribuciju u poređenju sa receptorom paratiroidnog hormona 2 (PTH1R). On se aktivira samo posredstvom PTH, a ne i PTHLH. on je posebno zastupljen u mozgu i pankreasu.^[1]

Reference

^ ^а ^б „Entrez Gene: PTH2R parathyroid hormone 2 receptor”.

Literatura

Usdin TB, Gruber C, Bonner TI (1995). „Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor.”. J. Biol. Chem. 270 (26): 15455—8. PMID 7797535. doi:10.1074/jbc.270.26.15455.
Usdin TB, Modi W, Bonner TI (1997). „Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization.”. Genomics. 37 (1): 140—1. PMID 8921382. doi:10.1006/geno.1996.0532.
Clark JA, Bonner TI, Kim AS, Usdin TB (1998). „Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors.”. Mol. Endocrinol. 12 (2): 193—206. PMID 9482662. doi:10.1210/me.12.2.193.
Hoare SR, Clark JA, Usdin TB (2000). „Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity.”. J. Biol. Chem. 275 (35): 27274—83. PMID 10854439. doi:10.1074/jbc.M003910200.
John MR; Arai M; Rubin DA; et al. (2002). „Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues.”. Endocrinology. 143 (3): 1047—57. PMID 11861531. doi:10.1210/en.143.3.1047.
Strausberg RL; Feingold EA; Grouse LH; et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899—903. PMC 139241 . PMID 12477932. doi:10.1073/pnas.242603899.
Seeliger S; Hausberg M; Eue I; et al. (2003). „The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism.”. Clin. Nephrol. 59 (6): 429—35. PMID 12834174.
Bisello A; Manen D; Pierroz DD; et al. (2004). „Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization.”. Mol. Endocrinol. 18 (6): 1486—98. PMID 14988434. doi:10.1210/me.2003-0487.
Gerhard DS; Wagner L; Feingold EA; et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121—7. PMC 528928 . PMID 15489334. doi:10.1101/gr.2596504.
Mahon MJ, Shimada M (2005). „Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors.”. FEBS Lett. 579 (3): 803—7. PMID 15670850. doi:10.1016/j.febslet.2004.12.056.

Vidi još

Receptor paratiroidnog hormona

Spoljašnje veze

„Parathyroid Hormone Receptors: PTH2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Архивирано из оригинала 03. 03. 2016. г.
Receptor,+Parathyroid+Hormone,+Type+2 на US National Library of Medicine Medical Subject Headings (MeSH)

Transmembranski receptor: receptori spregnuti s G proteinom

Klasa A: Rodopsinu slični

Neurotransmiter

Adrenergički	α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Purinski	Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
Serotoninski	(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi	Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)

Metaboliti i
signalni molekuli

Eikozanoidni	CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi	Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6) • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat

Peptid

Neuropeptidni

B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)

Drugi

Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)

Razno

Orfan	GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi	Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)

Klasa B: Sekretinu slični

Orfan	GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi	Moždano specifični angiogenezni inhibitor (1, 2, 3) • Kadherin (1, 2, 3) • Kalcitonin • CALCRL • CD97 • Kortikotropin-oslobađajući hormon (1, 2) • EMR (1, 2, 3) • Glukagon (GR, GIPR, GLP1R, GLP2R) • Hormon rasta • PACAPR1 • GPR • Latrofilin (1, 2, 3, ELTD1) • Metuzalemski protein • Paratiroidni hormon (1, 2) • Sekretin • Vazoaktivni intestinalni peptid (1, 2)

Klasa C: Metabotropni
glutamat / feromon

Ukus	TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi	Kalcijum-detektujući receptor • GABA B (1, 2) • Glutamatni receptor (Metabotropni glutamat (1, 2, 3, 4, 5, 6, 7, 8)) • GPRC6A • GPR (156, 158, 179) • RAIG (1, 2, 3, 4) • VNR (1, 2, 3, 5)