Minociklin
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| Klinički podaci | |
|---|---|
| Prodajno ime | Alti-Minocycline, Apo-Minocycline, Arestin, Dynacin |
| Drugs.com | Monografija |
| Način primene | Oralno |
| Farmakokinetički podaci | |
| Poluvreme eliminacije | 11-22 h |
| Identifikatori | |
| CAS broj | 10118-90-8  Y |
| ATC kod | A01AB23 (WHO), J01AA08 |
| PubChem | CID 24960 |
| DrugBank | DB01017 Y |
| ChemSpider | 16735907 Y |
| KEGG | C07225 Y |
| ChEBI | CHEBI:50694 Y |
| ChEMBL | CHEMBL1434 Y |
| Hemijski podaci | |
| Formula | C23H27N3O7 |
| Molarna masa | 457,476 |
SMILES
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InChI
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Minociklin je organsko jedinjenje, koje sadrži 23 atoma ugljenika i ima molekulsku masu od 457,476 Da.[1][2][3][4][5][6][7]
Osobine
| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 9 |
| Broj donora vodonika | 5 |
| Broj rotacionih veza | 3 |
| Particioni koeficijent[8] (ALogP) | 0,1 |
| Rastvorljivost[9] (logS, log(mol/L)) | -2,8 |
| Polarna površina[10] (PSA, Å2) | 164,6 |
Reference
- ^ Gough A, Chapman S, Wagstaff K, Emery P, Elias E: Minocycline induced autoimmune hepatitis and systemic lupus erythematosus-like syndrome. BMJ. 1996 Jan 20;312(7024):169-72. PMID 8563540
- ^ Chen M, Ona VO, Li M, Ferrante RJ, Fink KB, Zhu S, Bian J, Guo L, Farrell LA, Hersch SM, Hobbs W, Vonsattel JP, Cha JH, Friedlander RM: Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease. Nat Med. 2000 Jul;6(7):797-801. PMID 10888929
- ^ Tikka TM, Koistinaho JE: Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol. 2001 Jun 15;166(12):7527-33. PMID 11390507
- ^ Nirmalananthan N, Greensmith L: Amyotrophic lateral sclerosis: recent advances and future therapies. Curr Opin Neurol. 2005 Dec;18(6):712-9. PMID 16280684
- ^ Song Y, Wei EQ, Zhang WP, Zhang L, Liu JR, Chen Z: Minocycline protects PC12 cells from ischemic-like injury and inhibits 5-lipoxygenase activation. Neuroreport. 2004 Oct 5;15(14):2181-4. PMID 15371729
- ^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709
. PMID 21059682. doi:10.1093/nar/gkq1126. - ^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
- ^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
- Minocycline
- p
- r
- u
| Aminoglikozidi (Inhibitori inicijacija) |
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|---|---|---|---|---|---|
| Tetraciklinski antibiotici (tRNK vezivanje) |
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| Steroidni antibiotici |
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 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
Normativna kontrola  | |
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| Državne |
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| Ostale |
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Minociklin na srodnim projektima Vikipedije:
Mediji na Ostavi
Podaci na Vikipodacima
