Halotan

Halotan
Klinički podaci


Prodajno ime	Anestan, Chalothane, Fluktan, Fluothane
Drugs.com	Monografija
Način primene	Respiratorno (inhalacija)
Identifikatori
CAS broj	151-67-7^Y
ATC kod	N01AB01 (WHO)
PubChem	CID 3562
IUPHAR/BPS	2401
DrugBank	DB01159^Y
ChemSpider	3441^Y
KEGG	C07515^Y
ChEBI	CHEBI:5615^Y
ChEMBL	CHEMBL931^Y
Hemijski podaci
Formula	C₂HBrClF₃
Molarna masa	197,382
SMILES FC(F)(F)C(Cl)Br
InChI InChI=1S/C2HBrClF3/c3-1(4)2(5,6)7/h1H^Y Key:BCQZXOMGPXTTIC-UHFFFAOYSA-N^Y

Fizički podaci
Tačka topljenja	−118 °C (−180 °F)
Tačka ključanja	502 °C (936 °F)

Halotan je organsko jedinjenje, koje sadrži 2 atoma ugljenika i ima molekulsku masu od 197,382 Da.^[1]^[2]^[3]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	0
Broj donora vodonika	0
Broj rotacionih veza	1
Particioni koeficijent^[4] (ALogP)	2,5
Rastvorljivost^[5] (logS, log(mol/L))	-2,9
Polarna površina^[6] (PSA, Å²)	0,0

Reference

^ Bovill JG: Inhalation anaesthesia: from diethyl ether to xenon. Handb Exp Pharmacol. 2008;(182):121-42. PMID 18175089
^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.