Discoidin domain-containing receptor 2

DDR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2WUH, 2Z4F
Identifiers
Aliases	DDR2, MIG20a, NTRKR3, TKT, TYRO10, discoidin domain receptor tyrosine kinase 2, WRCN
External IDs	OMIM: 191311; MGI: 1345277; HomoloGene: 68505; GeneCards: DDR2; OMA:DDR2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q23.3 Start 162,631,373 bp[1] End 162,787,405 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 H3|1 76.84 cM Start 169,799,876 bp[2] End 169,938,331 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tail of epididymis tendon of biceps brachii vena cava synovial joint Achilles tendon caput epididymis cartilage tissue tibia buccal mucosa cell pericardium Top expressed in calvaria ascending aorta dermis lumbar spinal ganglion aortic valve body of femur fossa ankle iris stroma of bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transferase activity nucleotide binding protein kinase activity kinase activity protein binding transmembrane receptor protein tyrosine kinase activity protein tyrosine kinase collagen receptor activity protein tyrosine kinase activity ATP binding collagen binding Cellular component integral component of membrane membrane focal adhesion integral component of plasma membrane extracellular exosome apical plasma membrane plasma membrane actin cytoskeleton receptor complex Biological process collagen-activated tyrosine kinase receptor signaling pathway ossification phosphorylation collagen fibril organization transmembrane receptor protein tyrosine kinase signaling pathway regulation of bone mineralization positive regulation of fibroblast proliferation biomineral tissue development positive regulation of DNA-binding transcription factor activity extracellular matrix organization regulation of extracellular matrix disassembly positive regulation of extracellular matrix disassembly protein phosphorylation cell adhesion positive regulation of osteoblast differentiation chondrocyte proliferation positive regulation of cell population proliferation peptidyl-tyrosine phosphorylation endochondral bone growth positive regulation of fibroblast migration signal transduction positive regulation of protein kinase activity protein autophosphorylation regulation of cell-matrix adhesion cell-matrix adhesion cell differentiation regulation of extracellular matrix organization Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 4921 18214 Ensembl ENSG00000162733 ENSMUSG00000026674 UniProt Q16832 Q62371 RefSeq (mRNA) NM_001014796 NM_006182 NM_001354982 NM_001354983 NM_022563 RefSeq (protein) NP_001014796 NP_006173 NP_001341911 NP_001341912 NP_072075 Location (UCSC) Chr 1: 162.63 – 162.79 Mb Chr 1: 169.8 – 169.94 Mb PubMed search [3] [4]
Wikidata
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Discoidin domain-containing receptor 2, also known as CD167b (cluster of differentiation 167b), is a protein that in humans is encoded by the DDR2 gene.^[5] Discoidin domain-containing receptor 2 is a receptor tyrosine kinase (RTK).

Function

RTKs play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. In the case of DDR2, the ligand is collagen which binds to its extracellular discoidin domain.^[6] This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. DDR2 has been associated with a number of diseases including fibrosis and cancer.^[7]

Structure

RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain.^[5]

Gene

Alternative splicing in the 5' UTR of the DDR2 gene results in multiple transcript variants encoding the same protein.^[5]

Interactions

DDR2 (gene) has been shown to interact with SHC1^[8] and phosphorylate Shp2.^[9] DDR2 also interacts with Integrin α₁β₁ and α₂β₁ by promoting their adhesion to collagen.^[10]

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.