Related to receptor tyrosine kinase

RYK
Identifiers
Aliases	RYK, D3S3195, JTK5, JTK5A, RYK1, receptor-like tyrosine kinase, receptor like tyrosine kinase
External IDs	OMIM: 600524; MGI: 101766; HomoloGene: 68287; GeneCards: RYK; OMA:RYK - orthologs
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3q22.2 Start 134,065,303 bp[1] End 134,250,859 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 F1|9 54.72 cM Start 102,712,116 bp[2] End 102,785,504 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in buccal mucosa cell Achilles tendon left ovary saphenous vein gastric mucosa urethra ventricular zone germinal epithelium right ovary stromal cell of endometrium Top expressed in tail of embryo secondary oocyte genital tubercle ventricular zone zygote lip muscle of thigh epiblast calvaria molar More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein tyrosine kinase activity transferase activity transmembrane signaling receptor activity kinase activity Wnt-activated receptor activity ATP binding protein binding frizzled binding Wnt-protein binding coreceptor activity involved in Wnt signaling pathway, planar cell polarity pathway receptor tyrosine kinase transmembrane receptor protein tyrosine kinase activity protein kinase activity Cellular component cytoplasm integral component of membrane integral component of plasma membrane membrane plasma membrane nucleus receptor complex Biological process positive regulation of MAPK cascade corpus callosum development signal transduction canonical Wnt signaling pathway non-canonical Wnt signaling pathway neurogenesis commissural neuron axon guidance neuron projection development protein phosphorylation synapse assembly chemorepulsion of dopaminergic neuron axon neuron differentiation cell proliferation in midbrain phosphorylation axonogenesis axon guidance Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation midbrain dopaminergic neuron differentiation planar cell polarity pathway involved in axon guidance Wnt signaling pathway peptidyl-tyrosine phosphorylation skeletal system morphogenesis negative regulation of axon extension involved in axon guidance negative chemotaxis negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade transmembrane receptor protein tyrosine kinase signaling pathway nervous system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6259 20187 Ensembl ENSG00000163785 ENSMUSG00000032547 UniProt P34925 Q01887 RefSeq (mRNA) NM_001005861 NM_002958 NM_001042607 NM_013649 NM_001284258 RefSeq (protein) NP_001005861 NP_002949 NP_001036072 NP_001271187 NP_038677 Location (UCSC) Chr 3: 134.07 – 134.25 Mb Chr 9: 102.71 – 102.79 Mb PubMed search [3] [4]
Wikidata
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The related to receptor tyrosine kinase (RYK) gene encodes the protein Ryk.

The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, differing from other members at a number of conserved residues in the activation and nucleotide binding domains. This gene product belongs to a subfamily whose members do not appear to be regulated by phosphorylation in the activation segment. It has been suggested that mediation of biological activity by recruitment of a signaling-competent auxiliary protein may occur through an as yet uncharacterized mechanism. Two alternative splice variants have been identified, encoding distinct isoforms.^[5]

History

The gene encoding mouse RYK was first identified in 1992.^[6] Subsequently, cDNA encoding the RYK protein have been isolated from the following species.^[7]

• rat
• chicken
• Human
• Zebrafish
• Caenorhabditis elegans
• Drosophila

Structure

In common with other receptor tyrosine kinase family members, RYK is composed of three domains, an N-terminal, extracellular ligand-binding domain, a transmembrane spanning domain and a C-terminal intracellular domain. However, in contrast to other receptor tyrosine kinases the C-terminal domain of RYK is devoid of detectable kinase activity.^[7]

Function

RYK is involved in regulation of axon growth during development of the nervous system.^[8]

References

Further reading