JAM2

Protein-coding gene in the species Homo sapiens
JAM2
Identifiers
AliasesJAM2, C21orf43, CD322, JAM-B, JAMB, PRO245, VE-JAM, VEJAM, junctional adhesion molecule 2, IBGC8
External IDsOMIM: 606870; MGI: 1933820; HomoloGene: 10929; GeneCards: JAM2; OMA:JAM2 - orthologs
Gene location (Human)
Chromosome 21 (human)
Chr.Chromosome 21 (human)[1]
Chromosome 21 (human)
Genomic location for JAM2
Genomic location for JAM2
Band21q21.3Start25,639,258 bp[1]
End25,717,562 bp[1]
Gene location (Mouse)
Chromosome 16 (mouse)
Chr.Chromosome 16 (mouse)[2]
Chromosome 16 (mouse)
Genomic location for JAM2
Genomic location for JAM2
Band16|16 C3.3Start84,571,011 bp[2]
End84,622,816 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • vena cava

  • internal globus pallidus

  • ganglionic eminence

  • pericardium

  • gastric mucosa

  • tibial nerve

  • subcutaneous adipose tissue

  • canal of the cervix

  • trigeminal ganglion

  • myometrium
Top expressed in
  • interventricular septum

  • myocardium of ventricle

  • cumulus cell

  • right ventricle

  • cardiac muscles

  • iris

  • substantia nigra

  • extraocular muscle

  • stria vascularis

  • ciliary body
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • protein heterodimerization activity
Cellular component
  • integral component of membrane
  • cell junction
  • plasma membrane
  • integral component of plasma membrane
  • membrane
  • bicellular tight junction
Biological process
  • negative regulation of cell adhesion
  • extracellular matrix organization
  • leukocyte migration
  • cell-cell adhesion
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

58494

67374

Ensembl

ENSG00000154721

ENSMUSG00000053062

UniProt

P57087

Q9JI59

RefSeq (mRNA)

NM_001270407
NM_001270408
NM_021219

NM_023844

RefSeq (protein)

NP_001257336
NP_001257337
NP_067042

NP_076333

Location (UCSC)Chr 21: 25.64 – 25.72 MbChr 16: 84.57 – 84.62 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Junctional adhesion molecule B is a protein that in humans is encoded by the JAM2 gene.[5][6][7] JAM2 has also been designated as CD322 (cluster of differentiation 322).

Function

Tight junctions represent one mode of cell-to-cell adhesion in endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. The protein encoded by this immunoglobulin superfamily gene member is localized in the tight junctions between high endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types and may play a role in lymphocyte homing to secondary lymphoid organs.[7]

It is purported to promote lymphocyte transendothelial migration.[8] It might also be involved with endothelial cell polarity, by associating to cell polarity protein PARD3 (PAR-3), together with JAM3.[9]

Interactions

JAM2 has been shown to interact with PARD3.[9]

It also interacts with the integrin dimer VLA-4 (also called α4β1).[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000154721 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000053062 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Palmeri D, van Zante A, Huang CC, Hemmerich S, Rosen SD (Aug 2000). "Vascular endothelial junction-associated molecule, a novel member of the immunoglobulin superfamily, is localized to intercellular boundaries of endothelial cells". J Biol Chem. 275 (25): 19139–45. doi:10.1074/jbc.M003189200. PMID 10779521.
  6. ^ Cunningham SA, Arrate MP, Rodriguez JM, Bjercke RJ, Vanderslice P, Morris AP, Brock TA (Nov 2000). "A novel protein with homology to the junctional adhesion molecule. Characterization of leukocyte interactions". J Biol Chem. 275 (44): 34750–6. doi:10.1074/jbc.M002718200. PMID 10945976.
  7. ^ a b "Entrez Gene: JAM2 junctional adhesion molecule 2".
  8. ^ Johnson-Léger CA, Aurrand-Lions M, Beltraminelli N, Fasel N, Imhof BA (October 2002). "Junctional adhesion molecule-2 (JAM-2) promotes lymphocyte transendothelial migration". Blood. 100 (7): 2479–86. doi:10.1182/blood-2001-11-0098. PMID 12239159.
  9. ^ a b Ebnet K, Aurrand-Lions M, Kuhn A, Kiefer F, Butz S, Zander K, Meyer zu Brickwedde MK, Suzuki A, Imhof BA, Vestweber D (October 2003). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.
  10. ^ Cunningham SA, Rodriguez JM, Arrate MP, Tran TM, Brock TA (August 2002). "JAM2 interacts with alpha4beta1. Facilitation by JAM3". J. Biol. Chem. 277 (31): 27589–92. doi:10.1074/jbc.C200331200. PMID 12070135.

Further reading

  • Muller WA (2003). "Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response". Trends Immunol. 24 (6): 327–34. doi:10.1016/S1471-4906(03)00117-0. PMID 12810109.
  • Bazzoni G (2004). "The JAM family of junctional adhesion molecules". Curr. Opin. Cell Biol. 15 (5): 525–30. doi:10.1016/S0955-0674(03)00104-2. PMID 14519386.
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Arrate MP, Rodriguez JM, Tran TM, et al. (2002). "Cloning of human junctional adhesion molecule 3 (JAM3) and its identification as the JAM2 counter-receptor". J. Biol. Chem. 276 (49): 45826–32. doi:10.1074/jbc.M105972200. PMID 11590146.
  • Liang TW, Chiu HH, Gurney A, et al. (2002). "Vascular endothelial-junctional adhesion molecule (VE-JAM)/JAM 2 interacts with T, NK, and dendritic cells through JAM 3". J. Immunol. 168 (4): 1618–26. doi:10.4049/jimmunol.168.4.1618. PMID 11823489.
  • Gardiner K, Slavov D, Bechtel L, Davisson M (2002). "Annotation of human chromosome 21 for relevance to Down syndrome: gene structure and expression analysis". Genomics. 79 (6): 833–43. doi:10.1006/geno.2002.6782. PMID 12036298.
  • Cunningham SA, Rodriguez JM, Arrate MP, et al. (2002). "JAM2 interacts with alpha4beta1. Facilitation by JAM3". J. Biol. Chem. 277 (31): 27589–92. doi:10.1074/jbc.C200331200. PMID 12070135.
  • Aurrand-Lions M, Johnson-Leger C, Lamagna C, et al. (2004). "Junctional adhesion molecules and interendothelial junctions". Cells Tissues Organs (Print). 172 (3): 152–60. doi:10.1159/000066967. PMID 12476045. S2CID 34211576.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ebnet K, Aurrand-Lions M, Kuhn A, et al. (2004). "The junctional adhesion molecule (JAM) family members JAM-2 and JAM-3 associate with the cell polarity protein PAR-3: a possible role for JAMs in endothelial cell polarity". J. Cell Sci. 116 (Pt 19): 3879–91. doi:10.1242/jcs.00704. PMID 12953056.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Liu T, Qian WJ, Gritsenko MA, et al. (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". J. Proteome Res. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.

External links

  • JAM2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  • Overview of all the structural information available in the PDB for UniProt: Q9JI59 (Mouse Junctional adhesion molecule B) at the PDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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