MYO9B

Protein-coding gene in the species Homo sapiens
MYO9B
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5C5S, 5HPY

Identifiers
AliasesMYO9B, CELIAC4, MYR5, myosin IXB
External IDsOMIM: 602129; MGI: 106624; HomoloGene: 3058; GeneCards: MYO9B; OMA:MYO9B - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for MYO9B
Genomic location for MYO9B
Band19p13.11Start17,075,777 bp[1]
End17,214,537 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for MYO9B
Genomic location for MYO9B
Band8 B3.3|8 34.43 cMStart71,725,358 bp[2]
End71,813,357 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • spleen

  • ascending aorta

  • upper lobe of left lung

  • monocyte

  • right coronary artery

  • stromal cell of endometrium

  • popliteal artery

  • right lung

  • lymph node
Top expressed in
  • ascending aorta

  • internal carotid artery

  • external carotid artery

  • aortic valve

  • calvaria

  • submandibular gland

  • thymus

  • Paneth cell

  • vas deferens

  • blood
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • protein homodimerization activity
  • metal ion binding
  • calmodulin binding
  • microfilament motor activity
  • protein binding
  • actin binding
  • cytoskeletal motor activity
  • ATP binding
  • Roundabout binding
  • ADP binding
  • GTPase activator activity
  • ATPase activity
Cellular component
  • cytoplasm
  • membrane
  • cell cortex
  • actin cytoskeleton
  • perinuclear region of cytoplasm
  • cytoskeleton
  • myosin complex
  • actin filament
  • cytosol
Biological process
  • intracellular signal transduction
  • ARF protein signal transduction
  • Roundabout signaling pathway
  • actin filament-based movement
  • positive regulation of GTPase activity
  • regulation of Rho protein signal transduction
  • regulation of small GTPase mediated signal transduction
  • signal transduction
  • Rho protein signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4650

17925

Ensembl

ENSG00000099331

ENSMUSG00000004677

UniProt

Q13459

Q9QY06

RefSeq (mRNA)

NM_001130065
NM_004145

NM_001142322
NM_001142323
NM_015742

RefSeq (protein)

NP_001123537
NP_004136

n/a

Location (UCSC)Chr 19: 17.08 – 17.21 MbChr 8: 71.73 – 71.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

MYO9B is a gene that encodes the Myosin-IXb protein.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000099331 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004677 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bahler M, Kehrer I, Gordon L, Stoffler HE, Olsen AS (Sep 1997). "Physical mapping of human myosin-IXB (MYO9B), the human orthologue of the rat myosin myr 5, to chromosome 19p13.1". Genomics. 43 (1): 107–9. doi:10.1006/geno.1997.4776. PMID 9226381.
  6. ^ "Entrez Gene: MYO9B myosin IXB".

Further reading

  • Bement WM, Hasson T, Wirth JA, et al. (1994). "Identification and overlapping expression of multiple unconventional myosin genes in vertebrate cell types". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6549–53. Bibcode:1994PNAS...91.6549B. doi:10.1073/pnas.91.14.6549. PMC 44240. PMID 8022818.
  • Wirth JA, Jensen KA, Post PL, et al. (1997). "Human myosin-IXb, an unconventional myosin with a chimerin-like rho/rac GTPase-activating protein domain in its tail". J. Cell Sci. 109 (3): 653–61. doi:10.1242/jcs.109.3.653. PMID 8907710.
  • Post PL, Bokoch GM, Mooseker MS (1998). "Human myosin-IXb is a mechanochemically active motor and a GAP for rho". J. Cell Sci. 111 (7): 941–50. doi:10.1242/jcs.111.7.941. PMID 9490638.
  • Grewal PK, Jones AM, Maconochie M, et al. (2000). "Cloning of the murine unconventional myosin gene Myo9b and identification of alternative splicing". Gene. 240 (2): 389–98. doi:10.1016/S0378-1119(99)00459-X. PMID 10580159.
  • Post PL, Tyska MJ, O'Connell CB, et al. (2002). "Myosin-IXb is a single-headed and processive motor". J. Biol. Chem. 277 (14): 11679–83. doi:10.1074/jbc.M111173200. PMID 11801597.
  • Inoue A, Saito J, Ikebe R, Ikebe M (2002). "Myosin IXb is a single-headed minus-end-directed processive motor". Nat. Cell Biol. 4 (4): 302–6. doi:10.1038/ncb774. PMID 11901422. S2CID 12158370.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Van Belzen MJ, Meijer JW, Sandkuijl LA, et al. (2003). "A major non-HLA locus in celiac disease maps to chromosome 19". Gastroenterology. 125 (4): 1032–41. doi:10.1016/S0016-5085(03)01205-8. PMID 14517787.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Saeki N, Tokuo H, Ikebe M (2005). "BIG1 is a binding partner of myosin IXb and regulates its Rho-GTPase activating protein activity". J. Biol. Chem. 280 (11): 10128–34. doi:10.1074/jbc.M413415200. PMID 15644318.
  • Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
  • Monsuur AJ, de Bakker PI, Alizadeh BZ, et al. (2006). "Myosin IXB variant increases the risk of celiac disease and points toward a primary intestinal barrier defect". Nat. Genet. 37 (12): 1341–4. doi:10.1038/ng1680. PMID 16282976. S2CID 35506194.
  • Kambara T, Ikebe M (2006). "A unique ATP hydrolysis mechanism of single-headed processive myosin, myosin IX". J. Biol. Chem. 281 (8): 4949–57. doi:10.1074/jbc.M509141200. PMID 16338935.
  • Nishikawa M, Nishikawa S, Inoue A, et al. (2006). "A unique mechanism for the processive movement of single-headed myosin-IX". Biochem. Biophys. Res. Commun. 343 (4): 1159–64. doi:10.1016/j.bbrc.2006.03.057. PMID 16616011.
  • Amundsen SS, Monsuur AJ, Wapenaar MC, et al. (2006). "Association analysis of MYO9B gene polymorphisms with celiac disease in a Swedish/Norwegian cohort". Hum. Immunol. 67 (4–5): 341–5. doi:10.1016/j.humimm.2006.03.020. PMID 16720215.
  • Giordano M, Marano C, Mellai M, et al. (2007). "A family-based study does not confirm the association of MYO9B with celiac disease in the Italian population". Genes Immun. 7 (7): 606–8. doi:10.1038/sj.gene.6364331. PMID 16943798.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • van Bodegraven AA, Curley CR, Hunt KA, et al. (2007). "Genetic variation in myosin IXB is associated with ulcerative colitis". Gastroenterology. 131 (6): 1768–74. doi:10.1053/j.gastro.2006.09.011. PMID 17087940.
  • Núñez C, Márquez A, Varadé J, et al. (2007). "No evidence of association of the MYO9B polymorphisms with celiac disease in the Spanish population". Tissue Antigens. 68 (6): 489–92. doi:10.1111/j.1399-0039.2006.00699.x. PMID 17176439.

External links

  • Overview of all the structural information available in the PDB for UniProt: Q13459 (Human Unconventional myosin-IXb (MYO9B)) at the PDBe-KB.
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