Keratin 34

Protein-coding gene in the species Homo sapiens
KRT34
Identifiers
AliasesKRT34, HA4, Ha-4, KRTHA4, hHa4, Keratin 34, K34
External IDsOMIM: 602763; MGI: 1309994; HomoloGene: 31083; GeneCards: KRT34; OMA:KRT34 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for KRT34
Genomic location for KRT34
Band17q21.2Start41,377,669 bp[1]
End41,382,306 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for KRT34
Genomic location for KRT34
Band11 D|11 63.38 cMStart99,928,173 bp[2]
End99,932,380 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • testicle

  • stromal cell of endometrium

  • placenta

  • skin of abdomen

  • ectocervix

  • skin of leg

  • vagina

  • canal of the cervix

  • right lung

  • mucosa of esophagus
Top expressed in
  • lip

  • skin of back

  • hair follicle

  • skin of abdomen

  • dermis

  • skin of external ear

  • sexually immature organism

  • conjunctival fornix

  • medial head of gastrocnemius muscle

  • foregut
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • structural molecule activity
Cellular component
  • intermediate filament
  • extracellular exosome
  • extracellular space
  • cytosol
Biological process
  • epidermis development
  • keratinization
  • cornification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3885

16672

Ensembl

ENSG00000131737
ENSG00000262045

ENSMUSG00000043485

UniProt

O76011

Q9D646

RefSeq (mRNA)

NM_021013
NM_001386014

NM_027563

RefSeq (protein)

NP_066293

NP_081839

Location (UCSC)Chr 17: 41.38 – 41.38 MbChr 11: 99.93 – 99.93 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin, type I cuticular Ha4 is a protein that in humans is encoded by the KRT34 gene.[5][6][7][8]

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.[8]

See also

References

  1. ^ a b c ENSG00000262045 GRCh38: Ensembl release 89: ENSG00000131737, ENSG00000262045 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000043485 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Heid HW, Werner E, Franke WW (Feb 1987). "The complement of native alpha-keratin polypeptides of hair-forming cells: a subset of eight polypeptides that differ from epithelial cytokeratins". Differentiation. 32 (2): 101–19. doi:10.1111/j.1432-0436.1986.tb00562.x. PMID 2431943.
  6. ^ Rogers MA, Winter H, Wolf C, Heck M, Schweizer J (Nov 1998). "Characterization of a 190-kilobase pair domain of human type I hair keratin genes". J Biol Chem. 273 (41): 26683–91. doi:10.1074/jbc.273.41.26683. PMID 9756910.
  7. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  8. ^ a b "Entrez Gene: KRT34 keratin 34".

Further reading

  • Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635 (inactive 2024-04-03). PMID 7686952.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Raica M, Zylis D, Cîmpean AM (2007). "Cytokeratin 20, 34betaE12 and overexpression of HER-2/neu in urine cytology as predictors of recurrences in superficial urothelial carcinoma". Romanian Journal of Morphology and Embryology. 46 (1): 11–5. PMID 16286979.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
  • v
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects


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