MYO1G

Protein-coding gene in the species Homo sapiens

MYO1G
Identifiers
AliasesMYO1G, HA2, HLA-HA2, MHAG, myosin IG
External IDsOMIM: 600642 MGI: 1927091 HomoloGene: 27996 GeneCards: MYO1G
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for MYO1G
Genomic location for MYO1G
Band7p13Start44,962,662 bp[1]
End44,979,088 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for MYO1G
Genomic location for MYO1G
Band11|11 A1Start6,456,548 bp[2]
End6,470,965 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • thymus

  • blood

  • lymph node

  • cecum

  • appendix

  • spleen

  • pylorus

  • bone marrow cells

  • cardia
Top expressed in
  • lymph node

  • spleen

  • thymus

  • bone marrow

  • blood

  • subcutaneous adipose tissue

  • white adipose tissue

  • right lung lobe

  • submandibular gland

  • carotid body
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • nucleotide binding
  • calmodulin binding
  • phosphatidylinositol-3,4-bisphosphate binding
  • actin binding
  • phosphatidylinositol-4,5-bisphosphate binding
  • cytoskeletal motor activity
  • ATP binding
  • phosphatidylinositol-3,4,5-trisphosphate binding
  • lipid binding
Cellular component
  • cell projection
  • membrane
  • filopodium
  • plasma membrane
  • microvillus
  • phagocytic cup
  • extracellular exosome
  • leading edge membrane
  • myosin complex
  • lamellipodium
Biological process
  • T cell migration
  • T cell mediated immunity
  • adaptive immune response
  • Fc-gamma receptor signaling pathway involved in phagocytosis
  • cell gliding
  • immune system process
  • cell-substrate adhesion
  • phagocytosis
  • exocytosis
  • T cell meandering migration
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64005

246177

Ensembl

ENSG00000136286

ENSMUSG00000020437

UniProt

B0I1T2

Q5SUA5

RefSeq (mRNA)

NM_033054

NM_178440

RefSeq (protein)

NP_149043

NP_848534

Location (UCSC)Chr 7: 44.96 – 44.98 MbChr 11: 6.46 – 6.47 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin IG, also known as myosin 1G and MYO1G, is a protein that in humans is encoded by the MYO1G gene.[5] MYO1G is a member of class I unconventional myosins. Its expression is highly restricted to hematopoietic tissues and cells. It localises exclusively to the plasma membrane and is dependent on both the motor domain and the tail domain.[6] MYO1G regulates cell elasticity possibly by interaction plasma membrane and cortical actin in Jurkat T-cells.

Function

MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010].

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136286 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020437 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Myosin IG". Retrieved 24 December 2019.
  6. ^ Olety B, Wälte M, Honnert U, Schillers H, Bähler M (February 2010). "Myosin 1G (Myo1G) is a haematopoietic specific myosin that localises to the plasma membrane and regulates cell elasticity". FEBS Letters. 584 (3): 493–9. doi:10.1016/j.febslet.2009.11.096. PMID 19968988. S2CID 27557093.,

Further reading

  • Patino-Lopez G, Aravind L, Dong X, Kruhlak MJ, Ostap EM, Shaw S (March 2010). "Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain (Myo1PH)". J. Biol. Chem. 285 (12): 8675–86. doi:10.1074/jbc.M109.086959. PMC 2838290. PMID 20071333.
  • Larsen ME, Kornblit B, Larsen MV, Masmas TN, Nielsen M, Thiim M, Garred P, Stryhn A, Lund O, Buus S, Vindelov L (October 2010). "Degree of predicted minor histocompatibility antigen mismatch correlates with poorer clinical outcomes in nonmyeloablative allogeneic hematopoietic cell transplantation". Biol. Blood Marrow Transplant. 16 (10): 1370–81. doi:10.1016/j.bbmt.2010.03.022. PMID 20353833.
  • Lio HY, Tang JL, Wu J, Wu SJ, Lin CY, Yang YC (September 2010). "Minor histocompatibility antigen HA-1 and HA-2 polymorphisms in Taiwan: frequency and application in hematopoietic stem cell transplantation". Clin. Chem. Lab. Med. 48 (9): 1287–93. doi:10.1515/CCLM.2010.246. PMID 20509834. S2CID 32914575.
  • Sellami MH, Torjemane L, Espadas de Arias A, Kaabi H, Ladeb S, Ben Othman T, Poli F, Hmida S (2010). "Mismatch for the minor histocompatibility antigen HA-2 and GVHD occurrence in HLA-A*0201-positive Tunisian recipients of HSCs". Immunol. Invest. 39 (6): 611–20. doi:10.3109/08820131003775029. PMID 20653428. S2CID 38774267.
  • v
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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