KRT80

KRT80
Identifiers
AliasesKRT80, KB20, keratin 80
External IDsOMIM: 611161; MGI: 1921377; HomoloGene: 66610; GeneCards: KRT80; OMA:KRT80 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for KRT80
Genomic location for KRT80
Band12q13.13Start52,168,996 bp[1]
End52,192,014 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for KRT80
Genomic location for KRT80
Band15 F1|15Start101,245,325 bp[2]
End101,268,043 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • skin of abdomen

  • amniotic fluid

  • gums

  • vulva

  • human penis

  • oral cavity

  • islet of Langerhans

  • palpebral conjunctiva

  • parotid gland

  • minor salivary glands
Top expressed in
  • lip

  • esophagus

  • skin of back

  • right lung

  • right lung lobe

  • molar

  • conjunctival fornix

  • cornea

  • belly cord

  • left lung
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • protein binding
  • structural molecule activity
Cellular component
  • cytoplasm
  • desmosome
  • keratin filament
  • intermediate filament
  • cytosol
  • intermediate filament cytoskeleton
Biological process
  • keratinization
  • cornification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

144501

74127

Ensembl

ENSG00000167767

ENSMUSG00000037185

UniProt

Q6KB66

Q0VBK2

RefSeq (mRNA)

NM_001081492
NM_182507

NM_028770

RefSeq (protein)

NP_001074961
NP_872313

NP_083046

Location (UCSC)Chr 12: 52.17 – 52.19 MbChr 15: 101.25 – 101.27 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin 80, also known as KRT80, is a protein which humans is encoded by the KRT80 gene.[5][6]

Function

Keratins, such as KRT80, are filament proteins that make up one of the major structural fibers of epithelial cells.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167767 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000037185 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (July 2006). "New consensus nomenclature for mammalian keratins". J. Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  6. ^ "Entrez Gene: KRT80 keratin 80".
  7. ^ Rogers MA, Edler L, Winter H, Langbein L, Beckmann I, Schweizer J (March 2005). "Characterization of new members of the human type II keratin gene family and a general evaluation of the keratin gene domain on chromosome 12q13.13". J. Invest. Dermatol. 124 (3): 536–44. doi:10.1111/j.0022-202X.2004.23530.x. PMID 15737194.

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


  • v
  • t
  • e
Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects


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