KIF3B

KIF3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3B6U
Identifiers
Aliases	KIF3B, FLA8, HH0048, KLP-11, kinesin family member 3B, RP89
External IDs	OMIM: 603754; MGI: 107688; HomoloGene: 55849; GeneCards: KIF3B; OMA:KIF3B - orthologs
Gene location (Human) Chr. Chromosome 20 (human)[1] Band 20q11.21 Start 32,277,651 bp[1] End 32,335,011 bp[1]
Gene location (Mouse) Chr. Chromosome 2 (mouse)[2] Band 2 H1|2 75.41 cM Start 153,133,333 bp[2] End 153,175,310 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in middle temporal gyrus islet of Langerhans sperm bronchial epithelial cell renal medulla jejunal mucosa secondary oocyte Brodmann area 23 parietal lobe superior frontal gyrus Top expressed in spermatocyte spermatid seminiferous tubule retinal pigment epithelium superior frontal gyrus primary motor cortex entorhinal cortex subiculum lateral geniculate nucleus medulla oblongata More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding microtubule binding protein binding plus-end-directed microtubule motor activity ATP binding microtubule motor activity ATPase activity intraciliary transport particle B binding Cellular component cytoplasm intraciliary transport particle cytosol membrane microtubule cytoskeleton spindle plus-end kinesin complex midbody ciliary tip spindle microtubule extracellular exosome cytoskeleton microtubule axon cytoplasm centrosome kinesin II complex cell projection axon cilium kinesin complex Biological process plus-end-directed vesicle transport along microtubule antigen processing and presentation of exogenous peptide antigen via MHC class II mitotic spindle organization anterograde axonal transport positive regulation of cytokinesis mitotic spindle assembly determination of left/right symmetry mitotic centrosome separation retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum microtubule-based movement intraciliary transport involved in cilium assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9371 16569 Ensembl ENSG00000101350 ENSMUSG00000027475 UniProt O15066 Q61771 RefSeq (mRNA) NM_004798 NM_008444 RefSeq (protein) NP_004789 NP_032470 Location (UCSC) Chr 20: 32.28 – 32.34 Mb Chr 2: 153.13 – 153.18 Mb PubMed search [3] [4]
Wikidata
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Kinesin-like protein KIF3B is a protein that in humans is encoded by the KIF3B gene.^[5][6] KIF3B is an N-type protein that complexes with two other kinesin proteins to form two-headed anterograde motors.^[7] First, KIF3B forms a heterodimer with KIF3A (kinesin-like protein KIF3A); (KIF3A/3B), that is membrane-bound and has ATPase activity. Then KIFAP3 (KAP3, kinesin superfamily associated protein–3) binds to the tail domain to form a heterotrimeric motor.^[7] This motor has a plus end-directed microtubule sliding activity that exhibits a velocity of ~0.3 μm/s a.^[8] There are 14 kinesin protein families in the kinesin superfamily and KIF3B is part of the Kinesin-2 family, of kinesins that can all form heterotrimeric complexes.^[9] Expression of the three motor subunits is ubiquitous. The KIG3A/3B/KAP3 motors can transport 90 to 160 nm in diameter organelles.^[7]

There are many orthologous KIF3B genes that are expressed in Drosophila, the sea urchin, Bos taurus, Canis familiaris, Equus caballus, Felis catus, Macaca mulatta, Mus musculus, Pan troglodytes, and Rattus norvegicus.

Function

The heterotrimeric KIF3B/KIF3A/KAP3 motor machinery functions in the intracellular transport of multiple different molecules such as β-catenin and MT1-MMP.^[10][11] KIF3B activity has been implicated with various cellular processes such as intracellular movement of organelles, intraflagellar transport, chromosome movement during mitosis and meiosis, and cellular interaction with the extracellular matrix.^[6][12][13]

KIF3B also regulates the interaction of cancer cells with the extracellular matrix (ECM), in particular the transport of MT1-MMP to the cancer cell front is essential for collagen fiber matrix realignment and degradation.^[14][15]

Interactions

KIF3B has been shown to interact with the SMC3 subunit of the cohesin complex and with RAB4A.^[16]

References

Further reading