KRT32

Protein-coding gene in the species Homo sapiens


KRT32
Identifiers
AliasesKRT32, HA2, HKA2, KRTHA2, hHa2, keratin 32
External IDsOMIM: 602760; MGI: 1309995; HomoloGene: 68246; GeneCards: KRT32; OMA:KRT32 - orthologs
Gene location (Human)
Chromosome 17 (human)
Chr.Chromosome 17 (human)[1]
Chromosome 17 (human)
Genomic location for KRT32
Genomic location for KRT32
Band17q21.2Start41,459,513 bp[1]
End41,467,386 bp[1]
Gene location (Mouse)
Chromosome 11 (mouse)
Chr.Chromosome 11 (mouse)[2]
Chromosome 11 (mouse)
Genomic location for KRT32
Genomic location for KRT32
Band11 D|11 63.4 cMStart99,971,674 bp[2]
End99,979,052 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • hair follicle

  • skin of arm

  • periodontal fiber

  • nipple

  • human penis

  • skin of abdomen

  • skin of leg

  • vagina

  • pharynx

  • cervix
Top expressed in
  • lip

  • esophagus

  • superior surface of tongue

  • hair follicle

  • Ileal epithelium

  • skin of back

  • morula

  • urethra

  • skin of abdomen

  • extensor digitorum longus muscle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • structural molecule activity
Cellular component
  • intermediate filament
  • extracellular exosome
  • cytosol
Biological process
  • epidermis development
  • keratinization
  • cornification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

3882

16670

Ensembl

ENSG00000108759

ENSMUSG00000046095

UniProt

Q14532

Q62168

RefSeq (mRNA)

NM_002278

NM_001159374
NM_010665

RefSeq (protein)

NP_002269

NP_001152846

Location (UCSC)Chr 17: 41.46 – 41.47 MbChr 11: 99.97 – 99.98 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Keratin, type I cuticular Ha2 is a protein that in humans is encoded by the KRT32 gene.[5][6][7][8]

The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II hair keratin to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108759 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000046095 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Rogers MA, Nischt R, Korge B, Krieg T, Fink TM, Lichter P, Winter H, Schweizer J (Nov 1995). "Sequence data and chromosomal localization of human type I and type II hair keratin genes". Exp Cell Res. 220 (2): 357–62. doi:10.1006/excr.1995.1326. PMID 7556444.
  6. ^ Rogers MA, Winter H, Langbein L, Krieg T, Schweizer J (Dec 1996). "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5". J Invest Dermatol. 107 (4): 633–8. doi:10.1111/1523-1747.ep12584243. PMID 8823373.
  7. ^ Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW (Jul 2006). "New consensus nomenclature for mammalian keratins". J Cell Biol. 174 (2): 169–74. doi:10.1083/jcb.200603161. PMC 2064177. PMID 16831889.
  8. ^ a b "Entrez Gene: KRT32 keratin 32".

Further reading

  • Yu J, Yu DW, Checkla DM, et al. (1993). "Human hair keratins". J. Invest. Dermatol. 101 (1 Suppl): 56S–59S. doi:10.1111/1523-1747.ep12362635 (inactive 2024-04-03). PMID 7686952.{{cite journal}}: CS1 maint: DOI inactive as of April 2024 (link)
  • Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein–protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
  • Adkins JN, Varnum SM, Auberry KJ, et al. (2003). "Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry". Mol. Cell. Proteomics. 1 (12): 947–55. doi:10.1074/mcp.M200066-MCP200. PMID 12543931.
  • Langbein L, Rogers MA, Winter H, et al. (1999). "The catalog of human hair keratins. I. Expression of the nine type I members in the hair follicle". J. Biol. Chem. 274 (28): 19874–84. doi:10.1074/jbc.274.28.19874. PMID 10391933.
  • Heid HW, Moll I, Franke WW (1988). "Patterns of expression of trichocytic and epithelial cytokeratins in mammalian tissues. I. Human and bovine hair follicles". Differentiation. 37 (2): 137–57. doi:10.1111/j.1432-0436.1988.tb00805.x. PMID 2456239.
  • v
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Human
Microfilaments
and ABPs
Myofilament
Actins
Myosins
Other
Other
Intermediate
filaments
Type 1/2
(Keratin,
Cytokeratin)
Epithelial keratins
(soft alpha-keratins)
Hair keratins
(hard alpha-keratins)
Ungrouped alpha
Not alpha
Type 3
Type 4
Type 5
Microtubules
and MAPs
Tubulins
MAPs
Kinesins
Dyneins
Microtubule organising proteins
Microtubule severing proteins
Other
Catenins
Membrane
Other
Nonhuman
See also: cytoskeletal defects


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