• heterotrimerni G-proteinski kompleks • membrana plazme
Biološki proces
• prenos signala • signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
Vrsta
Čovek
Miš
Entrez
2770
14677
Ensembl
ENSG00000127955
ENSMUSG00000057614
UniProt
P63096
n/a
RefSeq (mRNA)
NM_002069
NM_010305
RefSeq (protein)
NP_002060
NP_034435
Lokacija (UCSC)
Chr 7: 79.6 - 79.69 Mb
Chr 5: 17.78 - 17.87 Mb
PubMed pretraga
[1]
[2]
GNAI1, Guanin nukleotid-vezujući protein G(i), alfa-1 podjedinica, je protein koji je kod ljudi kodiran GNAI1genom.[1][2]
Interaktivna mapa signalnih puteva
Kliknite na linkove gena, proteina i metabolita da prikažete članke.[3]
[[File:
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
|{{{bSize}}}px|alt=Nikotin na dopaminergijskim neuronima uredi]]
[[:File:
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
[[]]
| ]]
Nikotin na dopaminergijskim neuronima uredi
Interakcije
Za GNAI1 je bilo pokazano da ostvaruje interakcije sa GPR143,[4] RGS14,[5][6] RIC8A,[7] S1PR1,[8] RGS12[5] i RGS19.[9][10]
Reference
^Bray P, Carter A, Guo V, Puckett C, Kamholz J, Spiegel A, Nirenberg M (1987). „Human cDNA clones for an alpha subunit of Gi signal-transduction protein”. Proc Natl Acad Sci U S A. 84 (15): 5115—9. PMC 298804 . PMID 3110783. doi:10.1073/pnas.84.15.5115.
^The interactive pathway map can be edited at WikiPathways: „NicotineDopaminergic_WP1602”.
^Schiaffino, M V; d'Addio M; et al. (1999). „Ocular albinism: evidence for a defect in an intracellular signal transduction system”. Nat. Genet. UNITED STATES. 23 (1): 108—12. ISSN 1061-4036. PMID 10471510. doi:10.1038/12715.
^ абKimple, R J; De Vries L; et al. (2001). „RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity”. J. Biol. Chem. United States. 276 (31): 29275—81. ISSN 0021-9258. PMID 11387333. doi:10.1074/jbc.M103208200.
^Kimple, Randall J; Kimple Michelle E; et al. (2002). „Structural determinants for GoLoco-induced inhibition of nucleotide release by Galpha subunits”. Nature. England. 416 (6883): 878—81. ISSN 0028-0836. PMID 11976690. doi:10.1038/416878a.
^Tall, Gregory G; Krumins Andrejs M; Gilman Alfred G (2003). „Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor”. J. Biol. Chem. United States. 278 (10): 8356—62. ISSN 0021-9258. PMID 12509430. doi:10.1074/jbc.M211862200.
^Lee, M J; Evans M; Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway”. J. Biol. Chem. UNITED STATES. 271 (19): 11272—9. ISSN 0021-9258. PMID 8626678. doi:10.1074/jbc.271.19.11272.
^Woulfe, D S; Stadel J M (1999). „Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP”. J. Biol. Chem. UNITED STATES. 274 (25): 17718—24. ISSN 0021-9258. PMID 10364213. doi:10.1074/jbc.274.25.17718.
^De Vries, L; Elenko E; et al. (1996). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits”. Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (26): 15203—8. ISSN 0027-8424. PMC26381 . PMID 8986788. doi:10.1073/pnas.93.26.15203.
Literatura
Sidhu A, Niznik HB (2000). „Coupling of dopamine receptor subtypes to multiple and diverse G proteins.”. Int. J. Dev. Neurosci. 18 (7): 669—77. PMID 10978845. doi:10.1016/S0736-5748(00)00033-2.
Brown EJ, Frazier WA (2001). „Integrin-associated protein (CD47) and its ligands.”. Trends Cell Biol. 11 (3): 130—5. PMID 11306274. doi:10.1016/S0962-8924(00)01906-1.
Raymond JR; Mukhin YV; Gelasco A; et al. (2002). „Multiplicity of mechanisms of serotonin receptor signal transduction.”. Pharmacol. Ther. 92 (2-3): 179—212. PMID 11916537. doi:10.1016/S0163-7258(01)00169-3.
Jiang M, Pandey S, Tran VT, Fong HK (1991). „Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells.”. Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3907—11. PMC51562 . PMID 1902575. doi:10.1073/pnas.88.9.3907.
Gennity JM, Siess W (1991). „Thrombin inhibits the pertussis-toxin-dependent ADP-ribosylation of a novel soluble Gi-protein in human platelets.”. Biochem. J. 279 ( Pt 3): 643—50. PMC1151493 . PMID 1953657.
Itoh H; Toyama R; Kozasa T; et al. (1988). „Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs.”. J. Biol. Chem. 263 (14): 6656—64. PMID 2834384.
Bloch DB; Bloch KD; Iannuzzi M; et al. (1988). „The gene for the alpha i1 subunit of human guanine nucleotide binding protein maps near the cystic fibrosis locus.”. Am. J. Hum. Genet. 42 (6): 884—8. PMC1715192 . PMID 3130752.
Nagata K; Katada T; Tohkin M; et al. (1988). „GTP-binding proteins in human platelet membranes serving as the specific substrate of islet-activating protein, pertussis toxin.”. FEBS Lett. 237 (1-2): 113—7. PMID 3139448. doi:10.1016/0014-5793(88)80182-0.
Kagimoto S; Yamada Y; Kubota A; et al. (1994). „Human somatostatin receptor, SSTR2, is coupled to adenylyl cyclase in the presence of Gi alpha 1 protein.”. Biochem. Biophys. Res. Commun. 202 (2): 1188—95. PMID 7914078. doi:10.1006/bbrc.1994.2054.
Nitta K; Uchida K; Kawashima A; et al. (1994). „Identification of GTP-binding proteins in human glomeruli.”. Nippon Jinzo Gakkai shi. 36 (1): 9—12. PMID 8107314.
Law SF; Zaina S; Sweet R; et al. (1994). „Gi alpha 1 selectively couples somatostatin receptor subtype 3 to adenylyl cyclase: identification of the functional domains of this alpha subunit necessary for mediating the inhibition by somatostatin of cAMP formation.”. Mol. Pharmacol. 45 (4): 587—90. PMID 8183236.
Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A (1993). „Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy.”. Endocrinology. 132 (6): 2484—90. PMID 8504751. doi:10.1210/en.132.6.2484.
Laugwitz KL; Allgeier A; Offermanns S; et al. (1996). „The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families.”. Proc. Natl. Acad. Sci. U.S.A. 93 (1): 116—20. PMC40189 . PMID 8552586. doi:10.1073/pnas.93.1.116.
Andersson B; Wentland MA; Ricafrente JY; et al. (1996). „A "double adaptor" method for improved shotgun library construction.”. Anal. Biochem. 236 (1): 107—13. PMID 8619474. doi:10.1006/abio.1996.0138.
Lee MJ, Evans M, Hla T (1996). „The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway.”. J. Biol. Chem. 271 (19): 11272—9. PMID 8626678. doi:10.1074/jbc.271.19.11272.
De Vries L; Elenko E; Hubler L; et al. (1997). „GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits.”. Proc. Natl. Acad. Sci. U.S.A. 93 (26): 15203—8. PMC26381 . PMID 8986788. doi:10.1073/pnas.93.26.15203.
Popov S, Yu K, Kozasa T, Wilkie TM (1997). „The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro.”. Proc. Natl. Acad. Sci. U.S.A. 94 (14): 7216—20. PMC23796 . PMID 9207071. doi:10.1073/pnas.94.14.7216.
Shuey DJ; Betty M; Jones PG; et al. (1998). „RGS7 attenuates signal transduction through the G(alpha q) family of heterotrimeric G proteins in mammalian cells.”. J. Neurochem. 70 (5): 1964—72. PMID 9572280. doi:10.1046/j.1471-4159.1998.70051964.x.
. PMID 3110783. doi:10.1073/pnas.84.15.5115. 
1agr: Kompleks ALF4-aktiviranog Gi-alfa-1 sa RGS4
1as0: GTP-gama-S vezan G42V GIA1
1as2: GDP+PI vezan G42V GIA1
1as3: GDP vezan G42V GIA1
1bh2: A326S mutant inhibitorne alfa podjedinice
1bof: Gi-alfa-1 vezan za GDP i magnezijum
1cip: Gi-alfa-1 podjedinica guanin nukleotid-vezujućeg proteinskog kompleksa sa GTP analogom
1gdd: Tercijarne i kvaternarne strukturne promene u GIA1 indukovane GTP hidrolizom
1gfi: Strukture aktivne konformacije Gi-alfa 1 i mehanizam GTP hidrolize
1gg2: G proteinski heterotrimerni mutant Gi-alfa_1 (G203A) beta_1 gama_2 sa vezanim GDP
1gia: Struktura aktivnih konformacija GiA1 i mehanizam GTP hidrolize
1gil: Struktura aktivnih konformacija GiA1 i mehanizam GTP hidrolize
1git: Struktura GTP-vezujućeg proteina
1gp2: G proteinski heterotrimer Gi-alfa_1 beta_1 gama_2 sa vezanim GDP![1kjy: Struktura ljudskog G[alfa]i1 vezanog za GoLoco motiv RGS14](//upload.wikimedia.org/wikipedia/commons/thumb/e/ea/PDB_1kjy_EBI.jpg/180px-PDB_1kjy_EBI.jpg)
1kjy: Struktura ljudskog G[alfa]i1 vezanog za GoLoco motiv RGS14
1svk: Struktura K180P mutanta Gi alfa podjedinice vezane za AlF4 i GDP
1svs: Struktura K180P mutanta Gi alfa podjedinice vezane za GppNHp.
1y3a: Struktura G-alfa-I1 vezan za GDP-selektivni peptid daje uvid u guanin nukleotidnu razmenu
2g83: Struktura aktiviranog G-alfa-i1 vezanog za nukleotid selektivni peptid
2gtp: Struktura heterodimernog kompleksa ljudskog RGS1 i aktiviranog Gi alfa 1
2hlb: Strukturna baza za nukleotidnu razmenu G-alfa-i podjedinice i specifičnosti receptorskog sprezanja
2ihb: Struktura heterodimernog kompleksa ljudskog RGS10 i aktiviranog Gi alfa 3
2ik8: Struktura heterodimernog kompleksa ljudskog RGS16 i aktiviranog Gi alfa 1
2ode: Struktura heterodimernog kompleksa ljudskog RGS8 i aktiviranog Gi alfa 3
![1kjy: Struktura ljudskog G[alfa]i1 vezanog za GoLoco motiv RGS14](http://upload.wikimedia.org/wikipedia/commons/thumb/e/ea/PDB_1kjy_EBI.jpg/180px-PDB_1kjy_EBI.jpg)
