Hydroxycarboxylic acid receptor 3

Protein-coding gene in the species Homo sapiens
HCAR3
Identifiers
AliasesHCAR3, GPR109B, HCA3, HM74, PUMAG, Puma-g, Niacin receptor 2, hydroxycarboxylic acid receptor 3
External IDsOMIM: 606039; MGI: 1933383; HomoloGene: 130547; GeneCards: HCAR3; OMA:HCAR3 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for HCAR3
Genomic location for HCAR3
Band12q24.31Start122,714,756 bp[1]
End122,716,811 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for HCAR3
Genomic location for HCAR3
Band5|5 FStart124,001,633 bp[2]
End124,003,562 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • blood

  • granulocyte

  • gonad

  • spleen

  • monocyte

  • mucosa of esophagus

  • bone marrow

  • skin of abdomen

  • skin of leg

  • appendix
Top expressed in
  • granulocyte

  • esophagus

  • lip

  • skin of external ear

  • morula

  • subcutaneous adipose tissue

  • skin of back

  • transitional epithelium of urinary bladder

  • trachea

  • skin of abdomen
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • cell junction
  • plasma membrane
  • integral component of plasma membrane
  • membrane
Biological process
  • G protein-coupled receptor signaling pathway
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

8843

80885

Ensembl

ENSG00000255398

ENSMUSG00000045502

UniProt

P49019

Q9EP66

RefSeq (mRNA)

NM_006018

NM_030701

RefSeq (protein)

NP_006009

NP_109626

Location (UCSC)Chr 12: 122.71 – 122.72 MbChr 5: 124 – 124 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Hydroxycarboxylic acid receptor 3 (HCA3), also known as niacin receptor 2 (NIACR2) and GPR109B,[5] is a protein which in humans is encoded by the HCAR3 gene.[6][7] HCA3, like the other hydroxycarboxylic acid receptors HCA1 and HCA2, is a Gi/o-coupled G protein-coupled receptor (GPCR).[5][8] The primary endogenous agonists of HCA3 are 3-hydroxyoctanoic acid and kynurenic acid.[5][8][9] HCA3 is also a low-affinity biomolecular target for niacin (aka nicotinic acid).[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000255398 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000045502 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b c Offermanns S, Colletti SL, Lovenberg TW, Semple G, Wise A, IJzerman AP (June 2011). "International Union of Basic and Clinical Pharmacology. LXXXII: Nomenclature and Classification of Hydroxy-carboxylic Acid Receptors (GPR81, GPR109A, and GPR109B)". Pharmacological Reviews. 63 (2): 269–90. doi:10.1124/pr.110.003301. PMID 21454438.
  6. ^ "Entrez Gene: GPR109B G protein-coupled receptor 109B".
  7. ^ Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology. 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609.
  8. ^ a b S Offermanns, SL Colletti, AP IJzerman, TW Lovenberg, G Semple, A Wise, MG Waters. "Hydroxycarboxylic acid receptors". IUPHAR/BPS Guide to Pharmacology. International Union of Basic and Clinical Pharmacology. Retrieved 13 July 2018.{{cite web}}: CS1 maint: multiple names: authors list (link)
  9. ^ Kapolka, NJ; Taghon, GJ; Rowe, JB; Morgan, WM; Enten, JF; Lambert, NA; Isom, DG (9 June 2020). "DCyFIR: a high-throughput CRISPR platform for multiplexed G protein-coupled receptor profiling and ligand discovery". Proceedings of the National Academy of Sciences of the United States of America. 117 (23): 13117–13126. Bibcode:2020PNAS..11713117K. doi:10.1073/pnas.2000430117. PMC 7293659. PMID 32434907.
  10. ^ Peters, A; Krumbholz, P; Jäger, E; Heintz-Buschart, A; Çakir, MV; Rothemund, S; Gaudl, A; Ceglarek, U; Schöneberg, T; Stäubert, C (May 2019). "Metabolites of lactic acid bacteria present in fermented foods are highly potent agonists of human hydroxycarboxylic acid receptor 3". PLOS Genetics. 15 (5): e1008145. doi:10.1371/journal.pgen.1008145. PMC 6532841. PMID 31120900.

External links

  • "Nicotinic Acid Receptor Family: GPR109B". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from the original on 2016-03-03. Retrieved 2008-12-09.

Further reading

  • Nomura H, Nielsen BW, Matsushima K (October 1993). "Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors". International Immunology. 5 (10): 1239–49. doi:10.1093/intimm/5.10.1239. PMID 7505609.
  • Zingoni A, Rocchi M, Storlazzi CT, Bernardini G, Santoni A, Napolitano M (June 1997). "Isolation and chromosomal localization of GPR31, a human gene encoding a putative G protein-coupled receptor". Genomics. 42 (3): 519–23. doi:10.1006/geno.1997.4754. hdl:11573/245592. PMID 9205127.
  • Irobi J, Nelis E, Verhoeven K, De Vriendt E, Dierick I, De Jonghe P, Van Broeckhoven C, Timmerman V (June 2002). "Mutation analysis of 12 candidate genes for distal hereditary motor neuropathy type II (distal HMN II) linked to 12q24.3". Journal of the Peripheral Nervous System. 7 (2): 87–95. doi:10.1046/j.1529-8027.2002.02014.x. PMID 12090300. S2CID 8453412.
  • Wise A, Foord SM, Fraser NJ, Barnes AA, Elshourbagy N, Eilert M, Ignar DM, Murdock PR, Steplewski K, Green A, Brown AJ, Dowell SJ, Szekeres PG, Hassall DG, Marshall FH, Wilson S, Pike NB (March 2003). "Molecular identification of high and low affinity receptors for nicotinic acid". The Journal of Biological Chemistry. 278 (11): 9869–74. doi:10.1074/jbc.M210695200. PMID 12522134.
  • Tunaru S, Kero J, Schaub A, Wufka C, Blaukat A, Pfeffer K, Offermanns S (March 2003). "PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect". Nature Medicine. 9 (3): 352–5. doi:10.1038/nm824. PMID 12563315. S2CID 20451806.
  • Soga T, Kamohara M, Takasaki J, Matsumoto S, Saito T, Ohishi T, Hiyama H, Matsuo A, Matsushime H, Furuichi K (March 2003). "Molecular identification of nicotinic acid receptor". Biochemical and Biophysical Research Communications. 303 (1): 364–9. doi:10.1016/S0006-291X(03)00342-5. PMID 12646212.
  • Toulza E, Mattiuzzo NR, Galliano MF, Jonca N, Dossat C, Jacob D, de Daruvar A, Wincker P, Serre G, Guerrin M (2007). "Large-scale identification of human genes implicated in epidermal barrier function". Genome Biology. 8 (6): R107. doi:10.1186/gb-2007-8-6-r107. PMC 2394760. PMID 17562024.
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