GPR22

Protein-coding gene in the species Homo sapiens
GPR22
Identifiers
AliasesGPR22, G protein-coupled receptor 22
External IDsOMIM: 601910; MGI: 1920260; HomoloGene: 18420; GeneCards: GPR22; OMA:GPR22 - orthologs
Gene location (Human)
Chromosome 7 (human)
Chr.Chromosome 7 (human)[1]
Chromosome 7 (human)
Genomic location for GPR22
Genomic location for GPR22
Band7q22.3Start107,470,018 bp[1]
End107,475,684 bp[1]
Gene location (Mouse)
Chromosome 12 (mouse)
Chr.Chromosome 12 (mouse)[2]
Chromosome 12 (mouse)
Genomic location for GPR22
Genomic location for GPR22
Band12|12 A3Start31,756,866 bp[2]
End31,763,946 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • superior frontal gyrus

  • prefrontal cortex

  • testicle

  • dorsolateral prefrontal cortex

  • Brodmann area 9

  • anterior cingulate cortex

  • primary visual cortex

  • right frontal lobe

  • left ventricle

  • hippocampus proper
Top expressed in
  • subiculum

  • interventricular septum

  • subdivision of hippocampus

  • Region I of hippocampus proper

  • hippocampus proper

  • dentate gyrus

  • lobe of cerebellum

  • cerebellar vermis

  • primary motor cortex

  • piriform cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • peptide binding
  • signal transducer activity
  • G protein-coupled receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
  • integral component of plasma membrane
Biological process
  • cellular response to hormone stimulus
  • signal transduction
  • response to peptide
  • G protein-coupled receptor signaling pathway
  • cell projection organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

2845

73010

Ensembl

ENSG00000172209
ENSG00000283812

ENSMUSG00000044067

UniProt

Q99680
Q3KNS9

Q8BZL4

RefSeq (mRNA)

NM_005295

NM_175191

RefSeq (protein)

NP_005286
NP_005286.2

NP_780400

Location (UCSC)Chr 7: 107.47 – 107.48 MbChr 12: 31.76 – 31.76 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Probable G-protein coupled receptor 22 is a protein that in humans is encoded by the GPR22 gene.[5][6]

References

  1. ^ a b c ENSG00000283812 GRCh38: Ensembl release 89: ENSG00000172209, ENSG00000283812 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000044067 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF Jr, Lynch KR, George SR (Apr 1997). "Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes". Gene. 187 (1): 75–81. doi:10.1016/S0378-1119(96)00722-6. PMID 9073069.
  6. ^ "Entrez Gene: GPR22 G protein-coupled receptor 22".

Further reading

  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
  • Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Lee J, Hever A, Willhite D, et al. (2006). "Effects of RNA degradation on gene expression analysis of human postmortem tissues". FASEB J. 19 (10): 1356–8. doi:10.1096/fj.04-3552fje. PMID 15955843. S2CID 3200625.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
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