G-protein coupled receptor
7 transmembrane receptor (metabotropic glutamate family) |
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Identifiers |
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Symbol | 7tm_3 |
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Pfam | PF00003 |
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InterPro | IPR000337 |
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PROSITE | PDOC00754 |
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TCDB | 9.A.14 |
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OPM superfamily | 6 |
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OPM protein | 4or2 |
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CDD | cd13953 |
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Available protein structures: |
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Pfam | structures / ECOD |
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PDB | RCSB PDB; PDBe; PDBj |
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PDBsum | structure summary |
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The class C G-protein-coupled receptors (InterPro: IPR000337) are a class of G-protein coupled receptors that include the metabotropic glutamate receptors (InterPro: IPR000162) and several additional receptors.[1]
Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length.[1] This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptors.
Subfamilies
Calcium-sensing receptor-related
- extracellular calcium-sensing receptor-related InterPro: IPR000068
GABAB receptors
- GABAB receptor (gamma-aminobutyric acid) InterPro: IPR002455
- GABAB receptor 1 (GABBR1)
- GABAB receptor 2 (GABBR2)
Metabotropic glutamate receptors
RAIG
Taste receptors
Orphan
Other
References
- ^ a b Bräuner-Osborne H, Wellendorph P, Jensen AA (2007). "Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors". Curr Drug Targets. 8 (1): 169–84. doi:10.2174/138945007779315614. PMID 17266540.