Tasosartan

Chemical compound

ATC code

C09CA05 (WHO)

Legal statusLegal status

Withdrawn

Identifiers

IUPAC name

2,4-dimethyl-8-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-5,8-dihydropyrido[2,3-d]pyrimidin-7(6H)-one

CAS Number

145733-36-4^Y

PubChem CID

60919

IUPHAR/BPS

6898

DrugBank

DB01349^Y

ChemSpider

54890^N

UNII

48G92V856H

CompTox Dashboard (EPA)

DTXSID40163148

Chemical and physical dataFormulaC₂₃H₂₁N₇OMolar mass411.469 g·mol⁻¹ ^NY (what is this?) (verify)

Tasosartan is an angiotensin II receptor antagonist.

It was withdrawn from FDA review by the manufacturer after phase III clinical trials showed elevated transaminases (a sign of possible liver toxicity) in a significant number of participants given the drug.^[1]^[2]

References

^ Atkinson AJ, et al. (2007). Principles of clinical pharmacology. Amsterdam: Elsevier. p. 515. ISBN 978-0-12-369417-1.
^ Dina R, Jafari M (July 2000). "Angiotensin II-receptor antagonists: an overview". Am J Health Syst Pharm. 57 (13): 1231–41. doi:10.1093/ajhp/57.13.1231. PMID 10902066.

Antihypertensive drugs acting on the renin–angiotensin system (C09)

ACE inhibitors
("-pril")

AIIRAs
("-sartan")

Azilsartan
Candesartan
Eprosartan
Fimasartan
Irbesartan (+HCT)
Losartan (+HCT)
Olmesartan (+amlodipine, +amlodipine and HCT, +HCT)
Tasosartan^§
Telmisartan (+amlodipine, +HCT)
Valsartan (+amlodipine, +amlodipine and HCT, +HCT, +nebivolol)

Renin inhibitors
("-kiren")

Aliskiren (+amlodipine, +HCT, +amlodipine and HCT)
Remikiren^§

Dual ACE/NEP inhibitors

Gemopatrilat
Ilepatril
Omapatrilat
Sampatrilat

Neprilysin inhibitors

Sacubitril (+valsartan)

^#WHO-EM
^‡Withdrawn from market
Clinical trials:
- ^†Phase III
- ^§Never to phase III

v t e Angiotensin receptor modulators
ATRTooltip Angiotensin receptor	Agonists: Angiotensin II Angiotensin III Angiotensin IV L-163,491 Saralasin Antagonists: Abitesartan Azilsartan Candesartan Elisartan Embusartan Eprosartan EXP-3174 Fimasartan Forasartan Irbesartan Losartan Milfasartan Olmesartan Olodanrigan PD123319 Pomisartan Pratosartan Ripisartan Saprisartan Sparsentan Tasosartan Telmisartan Valsartan Zolasartan ACE inhibitors: Alacepril Benazepril Captopril Cilazapril Delapril Enalapril Enalaprilat Fosinopril Gemopatrilat Imidapril Lisinopril Moexipril Omapatrilat Perindopril Quinapril Quinaprilat Ramipril Rentiapril Rescinnamine Spirapril Spiraprilat Temocapril Trandolapril Zofenopril Zofenoprilat Renin inhibitors: Aliskiren Ciprokiren Ditekiren Enalkiren Imarikiren Pepstatin Remikiren Terlakiren Zankiren Propeptides: Angiotensinogen Angiotensin I
Combinations:	Amlodipine/valsartan Olmesartan/amlodipine Olmesartan/amlodipine/hydrochlorothiazide Valsartan/hydrochlorothiazide Valsartan/hydrochlorothiazide/amlodipine

Angiotensin receptor modulators

ATRTooltip Angiotensin receptor