Cilazapril
Antihypertensive drug of the ACE inhibitor class
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Preferred IUPAC name (1S,9S)-9-{[(2S)-1-Ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-10-oxooctahydro-6H-pyridazino[1,2-a][1,2]diazepine-1-carboxylic acid | |
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ECHA InfoCard | 100.168.764 |
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InChI
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Properties | |
Chemical formula | C22H31N3O5 |
Molar mass | 417.506 g·mol−1 |
log P | 2.212 |
Acidity (pKa) | 2.285 |
Basicity (pKb) | 11.712 |
Pharmacology | |
C09AA08 (WHO) | |
Routes of administration | Oral |
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Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references |
Chemical compound
Cilazapril is an angiotensin-converting enzyme inhibitor (ACE inhibitor) used for the treatment of hypertension and congestive heart failure.[1][2]
It was patented in 1982 and approved for medical use in 1990.[3]
Chemistry
Of the eight possible stereoisomers, only the all-(S)-form is medically viable.[citation needed]
Brand names
It is branded as Dynorm, Inhibace, Vascace and many other names in various countries. None of these are available in the United States as of May 2010.[4]
References
- ^ Szucs, T. (1991). "Cilazapril. A review". Drugs. 41 (Suppl 1): 18–24. doi:10.2165/00003495-199100411-00005. PMID 1712267. S2CID 261123720.
- ^ Jasek, W, ed. (2007). Austria-Codex (in German) (2007/2008 ed.). Vienna: Österreichischer Apothekerverlag. ISBN 978-3-85200-181-4.
- ^ Fischer, Jnos; Ganellin, C. Robin (2006). Analogue-based Drug Discovery. John Wiley & Sons. p. 469. ISBN 9783527607495.
- ^ "Cilazapril". Drugs.com. Retrieved 28 May 2010.
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("-pril")
- Sulfhydryl-containing: Captopril
- Rentiapril
- Zofenopril
- Dicarboxylate-containing: Enalapril#
- Benazepril
- Cilazapril
- Delapril
- Imidapril
- Lisinopril (+amlodipine, +HCT)
- Moexipril
- Perindopril (+indapamide)
- Quinapril (+HCT)
- Ramipril
- Spirapril
- Temocapril
- Trandolapril
- Phosphonate-containing: Ceronapril
- Fosinopril (+HCT)
- Other/ungrouped: Alacepril
("-sartan")
("-kiren")
- Gemopatrilat
- Ilepatril
- Omapatrilat
- Sampatrilat
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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