Chlorphenesin carbamate

Muscle relaxant drug
  • D01AE07 (WHO)
Pharmacokinetic dataExcretionurineIdentifiers
  • (3-(4-chlorophenoxy)-2-hydroxypropyl)carbamate
CAS Number
  • 886-74-8 checkY
  • chlorphenesin: 104-29-0 checkY
PubChem CID
  • 2724
ChemSpider
  • 2623
UNII
  • 57U5YI11WP
  • chlorphenesin: I670DAL4SZ checkY
KEGG
  • D00770
ChEBI
  • CHEBI:3642 checkY
ChEMBL
  • ChEMBL607710 checkY
CompTox Dashboard (EPA)
  • DTXSID0049028 Edit this at Wikidata
ECHA InfoCard100.002.902 Edit this at WikidataChemical and physical dataFormulaC10H12ClNO4Molar mass245.66 g·mol−13D model (JSmol)
  • Interactive image
Melting point86 to 92 °C (187 to 198 °F)
  • c1cc(ccc1OCC(COC(=O)N)O)Cl
InChI
  • InChI=1S/C10H12ClNO4/c11-7-1-3-9(4-2-7)15-5-8(13)6-16-10(12)14/h1-4,8,13H,5-6H2,(H2,12,14)
  • Key:SKPLBLUECSEIFO-UHFFFAOYSA-N

Chlorphenesin carbamate (Maolate, Musil) is a centrally acting muscle relaxant used to treat muscle pain and spasms.[1][2] Chlorphenesin carbamate is no longer used for this purpose in most developed nations due to the availability of much safer spasmolytics such as benzodiazepines.

Other central effects include sedation, anxiolysis, and dizziness.

Chlorphenesin

A related chemical, chlorphenesin (C9H11ClO3) without the carbamate group, is used as a preservative in products such as cosmetics. It has antifungal and some antibacterial properties, and is classified as an antifungal for topical use by the WHO.[3]

The major adverse effect from this preservative on skin is allergic contact sensitivity.[4][5] Systemic intoxication from transdermal use has not been observed, although the FDA discourages its use as an ingredient in nipple cream for nursing mothers.[6]

See also

References

  1. ^ Okuyama S, Aihara H (February 1987). "Antinociceptive effect of chlorphenesin carbamate in adjuvant arthritic rats". Research Communications in Chemical Pathology and Pharmacology. 55 (2): 147–60. PMID 3823606.
  2. ^ Kurachi M, Aihara H (September 1984). "Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats". Japanese Journal of Pharmacology. 36 (1): 7–13. doi:10.1254/jjp.36.7. PMID 6503049.
  3. ^ ATC code D01AE07
  4. ^ Brown R (May 1981). "Chlorphenesin sensitivity". Contact Dermatitis. 7 (3): 162. doi:10.1111/j.1600-0536.1981.tb04601.x. PMID 6456118. S2CID 37580364.
  5. ^ Burns DA (April 1986). "Allergic contact sensitivity to chlorphenesin". Contact Dermatitis. 14 (4): 246. doi:10.1111/j.1600-0536.1986.tb01234.x. PMID 2941223. S2CID 43810471.
  6. ^ "FDA Warns Consumers Against Using Mommy's Bliss Nipple Cream Product can be harmful to nursing infants". Food and Drug Administration.
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