Nantenin

Nantenine, Nandina domestica[1] bitkisinde ve ayrıca bazı Corydalis türlerinde bulunan bir alkaloiddir.[2] Hem a1 -adrenerjik reseptörünün[3] hem de serotonin 5-HT2A reseptörünün[4] bir antagonistidir ve MDMA'nın hayvanlarda hem davranışsal hem de fizyolojik etkilerini bloke eder.[5]

Kaynakça

  1. ^ "Serotonergic receptor antagonist from Nandina domestica Thunberg". Journal of Pharmaceutical Sciences. 73 (4): 568-70. April 1984. doi:10.1002/jps.2600730435. PMID 6726648. 
  2. ^ "Alkaloids of Corydalis slivenensis". Planta Medica. 44 (3): 168-70. March 1982. doi:10.1055/s-2007-971432. PMID 17402105. 
  3. ^ "Structure-activity relationship studies with (+/-)-nantenine derivatives for alpha1-adrenoceptor antagonist activity". European Journal of Pharmacology. 437 (3): 173-8. February 2002. doi:10.1016/S0014-2999(02)01303-1. PMID 11890906. 
  4. ^ "(+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners". Bioorganic & Medicinal Chemistry Letters. 19 (9): 2530-2. May 2009. doi:10.1016/j.bmcl.2009.03.048. PMC 2677726 $2. PMID 19328689. 
  5. ^ "Nantenine: an antagonist of the behavioral and physiological effects of MDMA in mice". Psychopharmacology. 173 (3–4): 270-7. May 2004. doi:10.1007/s00213-003-1741-2. PMID 14740148.