Satraplatin

Satraplatin
Klinički podaci


Drugs.com	Monografija
Identifikatori
CAS broj	129580-63-8^Y
ATC kod	L01XA04 (WHO)
PubChem	CID 123974
UNII	8D7B37T28G^Y
Sinonimi	BMY 45594 BMS 182751 (OC-6-43)-bis(acetato)amminedichlorocyclohexylamine platinum(IV)
Hemijski podaci
Formula	C₁₀H₂₂Cl₂N₂O₄Pt
Molarna masa	500,277
SMILES N.[Cl-].[Cl-].[Pt+4].CC(=O)[O-].CC(=O)[O-].NC1CCCCC1
InChI InChI=1S/C6H13N.2C2H4O2.2ClH.H3N.Pt/c7-6-4-2-1-3-5-6;21-2(3)4;;;;/h6H,1-5,7H2;21H3,(H,3,4);2*1H;1H3;/q;;;;;;+4/p-4^Y Key:CKNPWBAXEKSCRG-UHFFFAOYSA-J^Y

Satraplatin je organsko jedinjenje, koje sadrži 10 atoma ugljenika i ima molekulsku masu od 500,277 Da.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	6
Broj donora vodonika	2
Broj rotacionih veza	0
Particioni koeficijent^[1] (ALogP)	-7,8
Rastvorljivost^[2] (logS, log(mol/L))	-1,2
Polarna površina^[3] (PSA, Å²)	255,4

^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.