Nedaplatin

Nedaplatin
Klinički podaci

Drugs.com	Monografija
Identifikatori
CAS broj	95734-82-0^Y
ATC kod	none
PubChem	CID 6917890
UNII	8UQ3W6JXAN^Y
KEGG	D01416^Y
Hemijski podaci
Formula	C₂H₈N₂O₃Pt
Molarna masa	303,175
SMILES N.N.[Pt+2].[O-]CC(=O)[O-]
InChI InChI=1S/C2H3O3.2H3N.Pt/c3-1-2(4)5;;;/h1H2,(H,4,5);2*1H3;/q-1;;;+2/p-1^Y Key:GYAVMUDJCHAASE-UHFFFAOYSA-M^Y

Nedaplatin je organsko jedinjenje, koje sadrži 2 atoma ugljenika i ima molekulsku masu od 303,175 Da.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	5
Broj donora vodonika	2
Broj rotacionih veza	1
Particioni koeficijent^[1] (ALogP)	-3,3
Rastvorljivost^[2] (logS, log(mol/L))	2,5
Polarna površina^[3] (PSA, Å²)	170,4

^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.