Klofenamid : Osobine, Reference, Literatura, Spoljašnje veze Википедија

Klofenamid

Klofenamid
Klinički podaci


Drugs.com	Monografija
Identifikatori
CAS broj	671-95-4^Y
ATC kod	C03BA07 (WHO)
PubChem	CID 69594
ChemSpider	62797^Y
UNII	582ILN204B^Y
KEGG	D01822^Y
Hemijski podaci
Formula	C₆H₇ClN₂O₄S₂
Molarna masa	270,714
SMILES NS(=O)(=O)c1ccc(Cl)c(c1)S(=O)(=O)N
InChI InChI=1S/C6H7ClN2O4S2/c7-5-2-1-4(14(8,10)11)3-6(5)15(9,12)13/h1-3H,(H2,8,10,11)(H2,9,12,13)^Y Key:NENBAISIHCWPKP-UHFFFAOYSA-N^Y

Klofenamid je organsko jedinjenje, koje sadrži 6 atoma ugljenika i ima molekulsku masu od 270,714 Da.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	4
Broj donora vodonika	2
Broj rotacionih veza	2
Particioni koeficijent^[1] (ALogP)	-0,1
Rastvorljivost^[2] (logS, log(mol/L))	-2,4
Polarna površina^[3] (PSA, Å²)	137,1

^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.