Dihidralazin

Dihidralazin
Klinički podaci


Drugs.com	Monografija
Identifikatori
CAS broj	484-23-1^Y
ATC kod	C02DB01 (WHO)
PubChem	CID 10230
ChemSpider	9813^Y
UNII	PCU411F5L6^Y
KEGG	D07170^Y
ChEMBL	CHEMBL35505^Y
Hemijski podaci
Formula	C₈H₁₀N₆
Molarna masa	190,205
SMILES N\N=C\1/NN\C(=N/N)\c2ccccc12
InChI InChI=1S/C8H10N6/c9-11-7-5-3-1-2-4-6(5)8(12-10)14-13-7/h1-4H,9-10H2,(H,11,13)(H,12,14)^Y Key:VQKLRVZQQYVIJW-UHFFFAOYSA-N^Y

Dihidralazin je organsko jedinjenje, koje sadrži 8 atoma ugljenika i ima molekulsku masu od 190,205 Da.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	6
Broj donora vodonika	4
Broj rotacionih veza	0
Particioni koeficijent^[1] (ALogP)	-0,8
Rastvorljivost^[2] (logS, log(mol/L))	-1,5
Polarna površina^[3] (PSA, Å²)	100,8

^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.