Ceftazidim : Osobine, Reference, Literatura, Spoljašnje veze Википедија

Ceftazidim

Ceftazidim
Klinički podaci


Prodajno ime	Ceftazidima [INN-Spanish], Ceftazidime pentahydrate, Ceftazidime Sodium In Plastic Container, Ceftazidimum [INN-Latin]
Drugs.com	Monografija
Način primene	Intramaskularno, intravenozno
Farmakokinetički podaci
Poluvreme eliminacije	1,9 h

Identifikatori
CAS broj	78439-06-2^Y
ATC kod	J01DD02 (WHO)
PubChem	CID 5481173
DrugBank	DB00438^Y
ChemSpider	4587145^Y
KEGG	C06889^Y
ChEBI	CHEBI:3508^Y
ChEMBL	CHEMBL201^Y
Hemijski podaci
Formula	C₂₂H₂₂N₆O₇S₂
Molarna masa	546,576
SMILES [O-]C(=O)C1=C(CS[C@]2([H])[C@H](NC(=O)C(=N/OC(C)(C)C(O)=O)\C3=CSC(N)=N3)C(=O)N12)C[N+]1=CC=CC=C1
InChI InChI=1S/C22H22N6O7S2/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34)/b26-13-/t14-,18-/m1/s1^Y Key:ORFOPKXBNMVMKC-DWVKKRMSSA-N^Y

Ceftazidim je organsko jedinjenje, koje sadrži 22 atoma ugljenika i ima molekulsku masu od 546,576 Da.^[1]^[2]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	11
Broj donora vodonika	3
Broj rotacionih veza	9
Particioni koeficijent^[3] (ALogP)	-0,7
Rastvorljivost^[4] (logS, log(mol/L))	-5,3
Polarna površina^[5] (PSA, Å²)	244,8

^ Knox C, Law V, Jewison T, Liu P, Ly S, Frolkis A, Pon A, Banco K, Mak C, Neveu V, Djoumbou Y, Eisner R, Guo AC, Wishart DS (2011). „DrugBank 3.0: a comprehensive resource for omics research on drugs”. Nucleic Acids Res. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126. уреди
^ David S. Wishart; Craig Knox; An Chi Guo; Dean Cheng; Savita Shrivastava; Dan Tzur; Bijaya Gautam; Murtaza Hassanali (2008). „DrugBank: a knowledgebase for drugs, drug actions and drug targets”. Nucleic acids research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958. уреди
^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t. уреди
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e. уреди

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.