Azipramin

Azipramin
Klinički podaci

Drugs.com	Monografija
Identifikatori
CAS broj	58503-82-5^Y
ATC kod	None
PubChem	CID 65468
ChemSpider	58920^Y
UNII	1P9L1B4UIC^Y
Hemijski podaci
Formula	C₂₆H₂₆N₂
Molarna masa	366,498
SMILES CN(CCc1cc2cccc3CCc4ccccc4n1c23)Cc5ccccc5
InChI InChI=1S/C26H26N2/c1-27(19-20-8-3-2-4-9-20)17-16-24-18-23-12-7-11-22-15-14-21-10-5-6-13-25(21)28(24)26(22)23/h2-13,18H,14-17,19H2,1H3^Y Key:GMJAPDJBIOQXSW-UHFFFAOYSA-N^Y

Azipramin je organsko jedinjenje, koje sadrži 26 atoma ugljenika i ima molekulsku masu od 366,498 Da.

Osobine

Osobina	Vrednost
Broj akceptora vodonika	1
Broj donora vodonika	0
Broj rotacionih veza	5
Particioni koeficijent^[1] (ALogP)	6,5
Rastvorljivost^[2] (logS, log(mol/L))	-8,3
Polarna površina^[3] (PSA, Å²)	8,2

^ Ghose, A.K.; Viswanadhan V.N. & Wendoloski, J.J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragment Methods: An Analysis of AlogP and CLogP Methods”. J. Phys. Chem. A. 102: 3762—3772. doi:10.1021/jp980230o.
^ Tetko IV, Tanchuk VY, Kasheva TN, Villa AE (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Chem Inf. Comput. Sci. 41: 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl P.; Rohde B.; Selzer P. (2000). „Fast calculation of molecular polar surface area as a sum of fragment based contributions and its application to the prediction of drug transport properties”. J. Med. Chem. 43: 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.