Relkovaptan

(IUPAC) ime

1-({(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-[(3,4-dimethoxyphenyl)sulfonyl]-3-hydroxy-2,3-dihydro-1H-indol-2-yl}carbonyl)-L-prolinamide

Klinički podaci

Identifikatori

CAS broj

150375-75-0

ATC kod

nije dodeljen

PubChem^[1]^[2]

60943

Hemijski podaci

Formula

C₂₈H₂₇Cl₂N₃O₇S

Mol. masa

620.501

SMILES

eMolekuli & PubHem

InChI
InChI=1S/C28H27Cl2N3O7S/c1-39-23-12-10-17(15-24(23)40-2)41(37,38)33-21-11-9-16(29)14-19(21)28(36,18-6-3-4-7-20(18)30)25(33)27(35)32-13-5-8-22(32)26(31)34/h3-4,6-7,9-12,14-15,22,25,36H,5,8,13H2,1-2H3,(H2,31,34)/t22-,25-,28+/m0/s1^Y Key: CEBYCSRFKCEUSW-NAYZPBBASA-N^Y

Sinonimi

(2S)-1-[(2R,3S)-5-chloro-3-(2-chlorophenyl)-1-(3,4-dimethoxyphenyl)sulfonyl-3-hydroxy-2H-indole-2-carbonyl]pyrrolidine-2-carboxamide

Farmakoinformacioni podaci

Trudnoća

Pravni status

Relkovaptan (SR-49059) je nepeptidni inhibitor antidiuretskog hormonskog (vazopresinskog) receptora. On je selektivan za V1a tip receptora.^[3] On je pokazao pozitivne inicijalne rezultate u tretmanu Rejnoove bolesti, dismenoreje, i kao tokolitik,^[4] mada on još uvek nije odobren za kliničku upotrebu.

Literatura

↑ Li Q, Cheng T, Wang Y, Bryant SH (2010). „PubChem as a public resource for drug discovery.”. Drug Discov Today 15 (23-24): 1052-7. DOI:10.1016/j.drudis.2010.10.003. PMID 20970519. edit
↑ Evan E. Bolton, Yanli Wang, Paul A. Thiessen, Stephen H. Bryant (2008). „Chapter 12 PubChem: Integrated Platform of Small Molecules and Biological Activities”. Annual Reports in Computational Chemistry 4: 217-241. DOI:10.1016/S1574-1400(08)00012-1.
↑ Lemmens-Gruber R, Kamyar M. Vasopressin antagonists. Cellular and Molecular Life Sciences. 2006 Aug;63(15):1766-79. PMID 16794787
↑ Decaux G, Soupart A, Vassart G. Non-peptide arginine-vasopressin antagonists: the vaptans. Lancet. 2008 May 10;371(9624):1624-32. PMID 18468546