Aspartat kinaza

Aspartat kinaza
Aspartat kinaza homodimer, Arabidopsis thaliana
Identifikatori
EC broj 2.7.2.4
CAS broj 9012-50-4
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB RCSB PDB PDBe PDBj PDBsum
Pretraga
PMC articles
PubMed articles
NCBI Protein search

Aspartat kinaza (EC 2.7.2.4, aspartokinaza, AK, beta-aspartokinaza, aspartinska kinaza) je enzim sa sistematskim imenom ATP:L-aspartat 4-fosfotransferaza.[1][2][3][4][5][6] Ovaj enzim katalizuje sledeću hemijsku reakciju

ATP + L-aspartat {\displaystyle \rightleftharpoons } ADP + 4-fosfo-L-aspartat

Enzim iz Escherichia coli je multifunkcionalni protein, koji takođe katalizuje reakciju EC 1.1.1.3, homoserin dehidrogenaze.

Reference

  1. Black, S. (1962). „Conversion of aspartic acid to homoserine”. Methods Enzymol. 5: 820-827. 
  2. Paulus, H. and Gray, E. (1967). „Multivalent feedback inhibition of aspartokinase in Bacillus polymyxa. I. Kinetic studies”. J. Biol. Chem. 242: 4980-4986. PMID 6058940. 
  3. Starnes, W.L., Munk, P., Maul, S.B., Cunningham, G.N., Cox, D.J. and Shive, W. (1972). „Threonine-sensitive aspartokinase-homoserine dehydrogenase complex, amino acid composition, molecular weight, and subunit composition of the complex”. Biochemistry 11: 677-687. PMID 4551091. 
  4. Véron, M., Falcoz-Kelly, F. and Cohen, G.N. (1972). „The threonine-sensitive homoserine dehydrogenase and aspartokinase activities of Escherichia coli K12. The two catalytic activities are carried by two independent regions of the polypeptide chain”. Eur. J. Biochem. 28: 520-527. PMID 4562990. 
  5. Chassagnole, C., Rais, B., Quentin, E., Fell, D. A. and Mazat, J.-P. (2001). „An integrated study of threonine-pathway enzyme kinetics in Escherichia coli”. Biochem. J. 356: 415-423. 
  6. Curien, G., Ravanel, S., Robert, M. and Dumas, R. (2005). „Identification of six novel allosteric effectors of Arabidopsis thaliana aspartate kinase-homoserine dehydrogenase isoforms”. J. Biol. Chem. 280: 41178-41183. 

Literatura

  • Nicholas C. Price, Lewis Stevens (1999). Fundamentals of Enzymology: The Cell and Molecular Biology of Catalytic Proteins (Third izd.). USA: Oxford University Press. ISBN 019850229X. 
  • Eric J. Toone (2006). Advances in Enzymology and Related Areas of Molecular Biology, Protein Evolution (Volume 75 izd.). Wiley-Interscience. ISBN 0471205036. 
  • Branden C, Tooze J.. Introduction to Protein Structure. New York, NY: Garland Publishing. ISBN: 0-8153-2305-0. 
  • Irwin H. Segel. Enzyme Kinetics: Behavior and Analysis of Rapid Equilibrium and Steady-State Enzyme Systems (Book 44 izd.). Wiley Classics Library. ISBN 0471303097. 
  • Robert A. Copeland (2013). Evaluation of Enzyme Inhibitors in Drug Discovery: A Guide for Medicinal Chemists and Pharmacologists (2nd izd.). Wiley-Interscience. ISBN 111848813X. 
  • Gerhard Michal, Dietmar Schomburg (2012). Biochemical Pathways: An Atlas of Biochemistry and Molecular Biology (2nd izd.). Wiley. ISBN 0470146842. 

Vanjske veze

  • MeSH Aspartate+kinase
  • p
  • r
  • u
TemeTipovi
EC1 Oksidoreduktaze/spisak  • EC2 Transferaze/spisak  • EC3 Hidrolaze/spisak  • EC4 Lijaze/spisak  • EC5 Izomeraze/spisak  • EC6 Ligaze/spisak
B enzm: 1.1/2/3/4/5/6/7/8/10/11/13/14/15-18, 2.1/2/3/4/5/6/7/8, 2.7.10, 2.7.11-12, 3.1/2/3/4/5/6/7, 3.1.3.48, 3.4.21/22/23/24, 4.1/2/3/4/5/6, 5.1/2/3/4/99, 6.1-3/4/5-6