VPS72

Protein-coding gene in the species Homo sapiens
VPS72
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5FUG

Identifiers
AliasesVPS72, CFL1, Swc2, TCFL1, YL-1, YL1, vacuolar protein sorting 72 homolog
External IDsOMIM: 600607; MGI: 1202305; HomoloGene: 110905; GeneCards: VPS72; OMA:VPS72 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for VPS72
Genomic location for VPS72
Band1q21.3Start151,176,304 bp[1]
End151,195,321 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for VPS72
Genomic location for VPS72
Band3|3 F2.1Start95,018,333 bp[2]
End95,030,362 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • secondary oocyte

  • ganglionic eminence

  • Achilles tendon

  • gastrocnemius muscle

  • islet of Langerhans

  • smooth muscle tissue

  • stromal cell of endometrium

  • prefrontal cortex

  • popliteal artery

  • monocyte
Top expressed in
  • medial ganglionic eminence

  • neural tube

  • lip

  • internal carotid artery

  • external carotid artery

  • yolk sac

  • secondary oocyte

  • somite

  • triceps brachii muscle

  • ankle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • histone binding
Cellular component
  • nucleus
  • nucleoplasm
  • nuclear speck
  • protein-containing complex
Biological process
  • chromatin remodeling
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • somatic stem cell population maintenance
  • transcription, DNA-templated
  • histone exchange
  • chromatin organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6944

21427

Ensembl

ENSG00000163159

ENSMUSG00000008958

UniProt

Q15906

Q62481

RefSeq (mRNA)

NM_005997
NM_001271087
NM_001271088

NM_009336

RefSeq (protein)

NP_001258016
NP_001258017
NP_005988

NP_033362

Location (UCSC)Chr 1: 151.18 – 151.2 MbChr 3: 95.02 – 95.03 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Vacuolar protein sorting-associated protein 72 homolog is a protein that in humans is encoded by the VPS72 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163159 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000008958 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Horikawa I, Tanaka H, Yuasa Y, Suzuki M, Oshimura M (Mar 1995). "Molecular cloning of a novel human cDNA on chromosome 1q21 and its mouse homolog encoding a nuclear protein with DNA-binding ability". Biochemical and Biophysical Research Communications. 208 (3): 999–1007. doi:10.1006/bbrc.1995.1433. PMID 7702631.
  6. ^ "Entrez Gene: VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae)".

Further reading

  • Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Cai Y, Jin J, Florens L, Swanson SK, Kusch T, Li B, Workman JL, Washburn MP, Conaway RC, Conaway JW (Apr 2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". The Journal of Biological Chemistry. 280 (14): 13665–70. doi:10.1074/jbc.M500001200. PMID 15647280.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Denoeud F, Kapranov P, Ucla C, Frankish A, Castelo R, Drenkow J, Lagarde J, Alioto T, Manzano C, Chrast J, Dike S, Wyss C, Henrichsen CN, Holroyd N, Dickson MC, Taylor R, Hance Z, Foissac S, Myers RM, Rogers J, Hubbard T, Harrow J, Guigó R, Gingeras TR, Antonarakis SE, Reymond A (Jun 2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions". Genome Research. 17 (6): 746–59. doi:10.1101/gr.5660607. PMC 1891335. PMID 17567994.


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