TRIT1

Protein-coding gene in the species Homo sapiens
TRIT1
Identifiers
AliasesTRIT1, IPT, MOD5, GRO1, IPPT, IPTase, hGRO1, tRNA isopentenyltransferase 1, COXPD35
External IDsOMIM: 617840; MGI: 1914216; HomoloGene: 7010; GeneCards: TRIT1; OMA:TRIT1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for TRIT1
Genomic location for TRIT1
Band1p34.2Start39,838,110 bp[1]
End39,883,511 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for TRIT1
Genomic location for TRIT1
Band4|4 D2.2Start122,910,390 bp[2]
End122,948,742 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • oocyte

  • body of pancreas

  • vagina

  • skin of abdomen

  • right uterine tube

  • secondary oocyte

  • left lobe of thyroid gland

  • prostate

  • right lobe of thyroid gland

  • cerebellar hemisphere
Top expressed in
  • saccule

  • medullary collecting duct

  • renal corpuscle

  • otic placode

  • lacrimal gland

  • hair follicle

  • cumulus cell

  • fossa

  • condyle

  • brown adipose tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • transferase activity
  • nucleotide binding
  • ATP binding
  • metal ion binding
  • tRNA dimethylallyltransferase activity
  • nucleic acid binding
  • zinc ion binding
Cellular component
  • cytoplasm
  • mitochondrial matrix
  • mitochondrion
  • cellular component
Biological process
  • mitochondrial tRNA modification
  • tRNA processing
  • tRNA modification
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

54802

66966

Ensembl

ENSG00000043514

ENSMUSG00000028653

UniProt

Q9H3H1

Q80UN9

RefSeq (mRNA)

NM_001312691
NM_001312692
NM_017646

NM_025873

RefSeq (protein)

NP_001299620
NP_001299621
NP_060116

NP_080149

Location (UCSC)Chr 1: 39.84 – 39.88 MbChr 4: 122.91 – 122.95 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

tRNA isopentenyltransferase, mitochondrial is an enzyme that in humans is encoded by the TRIT1 gene.

It catalyzes the addition of an isopentenyl group from dimethylallyl diphosphate (DMAPP) onto adenosine residue 37 of certain tRNA molecules.[5][6][7]



References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000043514 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028653 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Golovko A, Hjalm G, Sitbon F, Nicander B (Jan 2001). "Cloning of a human tRNA isopentenyl transferase". Gene. 258 (1–2): 85–93. doi:10.1016/S0378-1119(00)00421-2. PMID 11111046.
  6. ^ Spinola M, Galvan A, Pignatiello C, Conti B, Pastorino U, Nicander B, Paroni R, Dragani TA (Aug 2005). "Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer". Oncogene. 24 (35): 5502–9. doi:10.1038/sj.onc.1208687. PMID 15870694.
  7. ^ "Entrez Gene: TRIT1 tRNA isopentenyltransferase 1".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Lemieux J, Lakowski B, Webb A, et al. (2002). "Regulation of physiological rates in Caenorhabditis elegans by a tRNA-modifying enzyme in the mitochondria". Genetics. 159 (1): 147–57. doi:10.1093/genetics/159.1.147. PMC 1461807. PMID 11560893.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  • Spinola M, Falvella FS, Galvan A, et al. (2007). "Ethnic differences in frequencies of gene polymorphisms in the MYCL1 region and modulation of lung cancer patients' survival" (PDF). Lung Cancer. 55 (3): 271–7. doi:10.1016/j.lungcan.2006.10.023. hdl:2434/25016. PMID 17145094.


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