TAOK2

Protein-coding gene in the species Homo sapiens

TAOK2

Identifiers

Aliases

TAOK2, MAP3K17, PSK, PSK1, PSK1-BETA, TAO1, TAO2, TAO kinase 2, Tao2beta

External IDs

OMIM: 613199; MGI: 1915919; HomoloGene: 74531; GeneCards: TAOK2; OMA:TAOK2 - orthologs

Gene location (Human)

Chr.	Chromosome 16 (human)^[1]

Band	16p11.2	Start	29,973,868 bp^[1]
Band	16p11.2	End	29,992,261 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 F3	Start	126,464,850 bp^[2]
Band	7\|7 F3	End	126,483,875 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right hemisphere of cerebellum

apex of heart

right adrenal cortex

right lung

right frontal lobe

anterior pituitary

right testis

left testis

left adrenal cortex

upper lobe of left lung

Top expressed in

neural layer of retina

superior frontal gyrus

dentate gyrus of hippocampal formation granule cell

granulocyte

primary visual cortex

ventricular zone

esophagus

yolk sac

spermatocyte

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity nucleotide binding protein kinase activity kinase activity protein serine/threonine kinase activity mitogen-activated protein kinase kinase binding ATP binding MAP kinase kinase kinase activity neuropilin binding tau protein binding tau-protein kinase activity
Cellular component	integral component of membrane cell projection membrane receptor complex dendrite nucleolus cytoskeleton cytoplasmic vesicle membrane nucleus cytoplasm cytosol cytoplasmic vesicle actin cytoskeleton axon neuron projection dendritic growth cone axonal growth cone
Biological process	phosphorylation protein targeting to membrane response to stress positive regulation of JNK cascade cellular response to DNA damage stimulus protein phosphorylation focal adhesion assembly stress-activated MAPK cascade regulation of cell growth regulation of cell shape cell migration actin cytoskeleton organization positive regulation of stress-activated MAPK cascade apoptotic process regulation of mitotic cell cycle nervous system development regulation of apoptotic process mitotic G2 DNA damage checkpoint signaling axonogenesis signal transduction stress-activated protein kinase signaling cascade positive regulation of protein autophosphorylation activation of protein kinase activity regulation of actin cytoskeleton organization protein autophosphorylation basal dendrite morphogenesis basal dendrite arborization
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9344


381921

Ensembl


ENSG00000149930


ENSMUSG00000059981

UniProt


Q9UL54


Q6ZQ29

RefSeq (mRNA)


NM_001252043 NM_004783 NM_016151


NM_001163774 NM_001163775

RefSeq (protein)


NP_001238972 NP_004774 NP_057235


NP_001157246 NP_001157247

Location (UCSC)

Chr 16: 29.97 – 29.99 Mb

Chr 7: 126.46 – 126.48 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Serine/threonine-protein kinase TAO2 is an enzyme that in humans is encoded by the TAOK2 gene.^[5]^[6]^[7]

Interactions

TAOK2 has been shown to interact with MAP2K6^[8] and MAP2K3.^[8]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000149930 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000059981 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, et al. (December 1998). "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 5 (6): 355–364. doi:10.1093/dnares/5.6.355. PMID 10048485.
^ Hutchison M, Berman KS, Cobb MH (October 1998). "Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades". The Journal of Biological Chemistry. 273 (44): 28625–28632. doi:10.1074/jbc.273.44.28625. PMID 9786855.
^ "Entrez Gene: TAOK2 TAO kinase 2".
^ ^a ^b Chen Z, Cobb MH (May 2001). "Regulation of stress-responsive mitogen-activated protein (MAP) kinase pathways by TAO2". The Journal of Biological Chemistry. 276 (19): 16070–16075. doi:10.1074/jbc.M100681200. PMID 11279118.

Chen Z, Hutchison M, Cobb MH (October 1999). "Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain". The Journal of Biological Chemistry. 274 (40): 28803–28807. doi:10.1074/jbc.274.40.28803. PMID 10497253.
Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JD (February 2000). "PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization". The Journal of Biological Chemistry. 275 (6): 4311–4322. doi:10.1074/jbc.275.6.4311. PMID 10660600.
Nakayama M, Kikuno R, Ohara O (November 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs". Genome Research. 12 (11): 1773–1784. doi:10.1101/gr.406902. PMC 187542. PMID 12421765.
Mitsopoulos C, Zihni C, Garg R, Ridley AJ, Morris JD (May 2003). "The prostate-derived sterile 20-like kinase (PSK) regulates microtubule organization and stability". The Journal of Biological Chemistry. 278 (20): 18085–18091. doi:10.1074/jbc.M213064200. PMID 12639963.
Chen Z, Raman M, Chen L, Lee SF, Gilman AG, Cobb MH (June 2003). "TAO (thousand-and-one amino acid) protein kinases mediate signaling from carbachol to p38 mitogen-activated protein kinase and ternary complex factors". The Journal of Biological Chemistry. 278 (25): 22278–22283. doi:10.1074/jbc.M301173200. PMID 12665513.
Yustein JT, Xia L, Kahlenburg JM, Robinson D, Templeton D, Kung HJ (September 2003). "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38". Oncogene. 22 (40): 6129–6141. doi:10.1038/sj.onc.1206605. PMID 13679851.
Huangfu WC, Omori E, Akira S, Matsumoto K, Ninomiya-Tsuji J (September 2006). "Osmotic stress activates the TAK1-JNK pathway while blocking TAK1-mediated NF-kappaB activation: TAO2 regulates TAK1 pathways". The Journal of Biological Chemistry. 281 (39): 28802–28810. doi:10.1074/jbc.M603627200. PMC 1797068. PMID 16893890.
Zihni C, Mitsopoulos C, Tavares IA, Baum B, Ridley AJ, Morris JD (March 2007). "Prostate-derived sterile 20-like kinase 1-alpha induces apoptosis. JNK- and caspase-dependent nuclear localization is a requirement for membrane blebbing". The Journal of Biological Chemistry. 282 (9): 6484–6493. doi:10.1074/jbc.M608336200. PMID 17158878.
Wojtala RL, Tavares IA, Morton PE, Valderrama F, Thomas NS, Morris JD (August 2011). "Prostate-derived sterile 20-like kinases (PSKs/TAOKs) are activated in mitosis and contribute to mitotic cell rounding and spindle positioning". The Journal of Biological Chemistry. 286 (34): 30161–30170. doi:10.1074/jbc.M111.228320. PMC 3191055. PMID 21705329.
de Anda FC, Rosario AL, Durak O, Tran T, Gräff J, Meletis K, et al. (June 2012). "Autism spectrum disorder susceptibility gene TAOK2 affects basal dendrite formation in the neocortex". Nature Neuroscience. 15 (7): 1022–1031. doi:10.1038/nn.3141. PMC 4017029. PMID 22683681.
Tavares IA, Touma D, Lynham S, Troakes C, Schober M, Causevic M, et al. (May 2013). "Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease". The Journal of Biological Chemistry. 288 (21): 15418–15429. doi:10.1074/jbc.M112.448183. PMC 3663559. PMID 23585562.
Koo CY, Giacomini C, Reyes-Corral M, Olmos Y, Tavares IA, Marson CM, et al. (November 2017). "Targeting TAO Kinases Using a New Inhibitor Compound Delays Mitosis and Induces Mitotic Cell Death in Centrosome Amplified Breast Cancer Cells". Molecular Cancer Therapeutics. 16 (11): 2410–2421. doi:10.1158/1535-7163.MCT-17-0077. PMID 28830982.
Richter M, Murtaza N, Scharrenberg R, White SH, Johanns O, Walker S, et al. (September 2019). "Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling". Molecular Psychiatry. 24 (9): 1329–1350. doi:10.1038/s41380-018-0025-5. PMC 6756231. PMID 29467497.
Giacomini C, Koo CY, Yankova N, Tavares IA, Wray S, Noble W, et al. (May 2018). "A new TAO kinase inhibitor reduces tau phosphorylation at sites associated with neurodegeneration in human tauopathies". Acta Neuropathologica Communications. 6 (1): 37. doi:10.1186/s40478-018-0539-8. PMC 5937037. PMID 29730992.
Scharrenberg R, Richter M, Johanns O, Meka DP, Rücker T, Murtaza N, et al. (September 2022). "TAOK2 rescues autism-linked developmental deficits in a 16p11.2 microdeletion mouse model". Molecular Psychiatry. 27 (11): 4707–4721. doi:10.1038/s41380-022-01785-3. PMC 9734055. PMID 36123424. S2CID 252382956.