SURF6

Gene in humans
SURF6
Identifiers
AliasesSURF6, RRP14, surfeit 6
External IDsOMIM: 185642; MGI: 98447; HomoloGene: 133981; GeneCards: SURF6; OMA:SURF6 - orthologs
Gene location (Human)
Chromosome 9 (human)
Chr.Chromosome 9 (human)[1]
Chromosome 9 (human)
Genomic location for SURF6
Genomic location for SURF6
Band9q34.2Start133,328,776 bp[1]
End133,336,188 bp[1]
Gene location (Mouse)
Chromosome 2 (mouse)
Chr.Chromosome 2 (mouse)[2]
Chromosome 2 (mouse)
Genomic location for SURF6
Genomic location for SURF6
Band2 A3|2 19.08 cMStart26,778,640 bp[2]
End26,792,891 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sural nerve

  • mucosa of transverse colon

  • gastrocnemius muscle

  • substantia nigra

  • C1 segment

  • granulocyte

  • temporal lobe

  • small intestine

  • amygdala

  • hypothalamus
Top expressed in
  • epiblast

  • external carotid artery

  • internal carotid artery

  • primitive streak

  • ascending aorta

  • supraoptic nucleus

  • aortic valve

  • lacrimal gland

  • hair follicle

  • prostate
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • RNA binding
Cellular component
  • nucleolus
  • nucleus
  • nucleoplasm
  • granular component
  • cytosolic large ribosomal subunit
Biological process
  • ribosome biogenesis
  • ribosomal large subunit biogenesis
  • ribosomal small subunit biogenesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6838

20935

Ensembl

ENSG00000148296
ENSG00000281309

ENSMUSG00000036160

UniProt

O75683

P70279

RefSeq (mRNA)

NM_001278942
NM_006753

NM_009298

RefSeq (protein)

NP_001265871
NP_006744

NP_033324

Location (UCSC)Chr 9: 133.33 – 133.34 MbChr 2: 26.78 – 26.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Surfeit locus protein 6 is a protein that in humans is encoded by the SURF6 gene.[5][6]

This gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity. The gene demonstrates features of a housekeeping gene, being ubiquitously expressed, and the encoded protein has been localized to the nucleolus. The protein includes motifs found in both the mouse and fish orthologs, which suggests a putative function as a nucleolar-matrix protein with nucleic acid-binding properties, based on characteristics determined in mouse.[6]

References

  1. ^ a b c ENSG00000281309 GRCh38: Ensembl release 89: ENSG00000148296, ENSG00000281309 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000036160 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Duhig T, Ruhrberg C, Mor O, Fried M (May 1999). "The human Surfeit locus". Genomics. 52 (1): 72–8. doi:10.1006/geno.1998.5372. PMID 9740673.
  6. ^ a b "Entrez Gene: SURF6 surfeit 6".

Further reading

  • Yon J, Jones T, Garson K, et al. (1993). "The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1". Hum. Mol. Genet. 2 (3): 237–40. doi:10.1093/hmg/2.3.237. PMID 8499913.
  • Magoulas C, Fried M (1996). "The Surf-6 gene of the mouse surfeit locus encodes a novel nucleolar protein". DNA Cell Biol. 15 (4): 305–16. doi:10.1089/dna.1996.15.305. PMID 8639267.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Magoulas C, Zatsepina OV, Jordan PW, et al. (1998). "The SURF-6 protein is a component of the nucleolar matrix and has a high binding capacity for nucleic acids in vitro". Eur. J. Cell Biol. 75 (2): 174–83. doi:10.1016/s0171-9335(98)80059-9. PMID 9548374.
  • Magoulas C, Fried M (2000). "Isolation and genomic analysis of the human surf-6 gene: a member of the Surfeit locus". Gene. 243 (1–2): 115–23. doi:10.1016/S0378-1119(99)00551-X. PMID 10675619.
  • Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
  • Angiolillo A, Russo G, Porcellini A, et al. (2002). "The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts". Gene. 284 (1–2): 169–78. doi:10.1016/S0378-1119(02)00379-7. PMID 11891058.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.


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