SPRY4

Protein-coding gene in the species Homo sapiens
SPRY4
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3BUN

Identifiers
AliasesSPRY4, HH17, sprouty RTK signaling antagonist 4
External IDsOMIM: 607984 MGI: 1345144 HomoloGene: 8042 GeneCards: SPRY4
Gene location (Human)
Chromosome 5 (human)
Chr.Chromosome 5 (human)[1]
Chromosome 5 (human)
Genomic location for SPRY4
Genomic location for SPRY4
Band5q31.3Start142,310,427 bp[1]
End142,326,455 bp[1]
Gene location (Mouse)
Chromosome 18 (mouse)
Chr.Chromosome 18 (mouse)[2]
Chromosome 18 (mouse)
Genomic location for SPRY4
Genomic location for SPRY4
Band18 B3|18 20.5 cMStart38,719,300 bp[2]
End38,734,468 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • left coronary artery

  • right lung

  • ascending aorta

  • upper lobe of left lung

  • right coronary artery

  • lower lobe of lung

  • left adrenal gland

  • left lobe of thyroid gland

  • anterior pituitary

  • right lobe of thyroid gland
Top expressed in
  • secondary oocyte

  • left lung lobe

  • entorhinal cortex

  • nasolacrimal duct

  • aortic valve

  • ankle

  • intercostal muscle

  • tongue

  • ascending aorta

  • brown adipose tissue
More reference expression data
BioGPS


More reference expression data
Gene ontology
Molecular function
  • protein binding
Cellular component
  • ruffle membrane
  • plasma membrane
  • cell projection
  • membrane
  • focal adhesion
  • cytoplasm
  • cytosol
Biological process
  • multicellular organism development
  • negative regulation of ERK1 and ERK2 cascade
  • regulation of signal transduction
  • negative regulation of fibroblast growth factor receptor signaling pathway
  • negative regulation of MAP kinase activity
  • negative regulation of Ras protein signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

81848

24066

Ensembl

ENSG00000187678

ENSMUSG00000024427

UniProt

Q9C004

Q9WTP2

RefSeq (mRNA)

NM_001127496
NM_001293289
NM_001293290
NM_030964

NM_011898

RefSeq (protein)

NP_001120968
NP_001280218
NP_001280219
NP_112226

NP_036028

Location (UCSC)Chr 5: 142.31 – 142.33 MbChr 18: 38.72 – 38.73 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein sprouty homolog 4 is a protein that in humans is encoded by the SPRY4 gene.[5][6]

Function

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[6]

Interactions

SPRY4 has been shown to interact with TESK1.[7]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000187678 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024427 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Katoh Y, Katoh M (Mar 2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells". International Journal of Molecular Medicine. 17 (3): 529–32. doi:10.3892/ijmm.17.3.529. PMID 16465403.
  6. ^ a b "Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila)".
  7. ^ Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

Further reading

  • Zaharieva I, Georgieva L, Nikolov I, Kirov G, Owen MJ, O'Donovan MC, Toncheva D (2008). "Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping". BMC Psychiatry. 8: 11. doi:10.1186/1471-244X-8-11. PMC 2268687. PMID 18298822.
  • Cabrita MA, Jäggi F, Widjaja SP, Christofori G (Sep 2006). "A functional interaction between sprouty proteins and caveolin-1". The Journal of Biological Chemistry. 281 (39): 29201–12. doi:10.1074/jbc.M603921200. PMID 16877379.
  • Wang J, Thompson B, Ren C, Ittmann M, Kwabi-Addo B (May 2006). "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer". The Prostate. 66 (6): 613–24. doi:10.1002/pros.20353. PMID 16388505. S2CID 43803094.
  • Ding W, Bellusci S, Shi W, Warburton D (Jul 2004). "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis". American Journal of Physiology. Lung Cellular and Molecular Physiology. 287 (1): L52-9. doi:10.1152/ajplung.00430.2003. PMID 14977631.
  • Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M, Kuriyama M, Saito N, Shibuya M, Yoshimura A (May 2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1". Nature Cell Biology. 5 (5): 427–32. doi:10.1038/ncb978. PMID 12717443. S2CID 33846459.
  • Leeksma OC, Van Achterberg TA, Tsumura Y, Toshima J, Eldering E, Kroes WG, Mellink C, Spaargaren M, Mizuno K, Pannekoek H, de Vries CJ (May 2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1". European Journal of Biochemistry. 269 (10): 2546–56. doi:10.1046/j.1432-1033.2002.02921.x. PMID 12027893.

External links

  • PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein sprouty homolog 4 (SPRY4)


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