SMCP

Protein-coding gene in the species Homo sapiens
SMCP
Identifiers
AliasesSMCP, HSMCSGEN1, MCS, MCSP, sperm mitochondria associated cysteine rich protein
External IDsOMIM: 601148; MGI: 96945; HomoloGene: 136205; GeneCards: SMCP; OMA:SMCP - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SMCP
Genomic location for SMCP
Band1q21.3Start152,878,322 bp[1]
End152,885,047 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for SMCP
Genomic location for SMCP
Band3|3 F1Start92,491,174 bp[2]
End92,496,304 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • sperm

  • caput epididymis

  • corpus epididymis

  • rhombencephalon

  • metencephalon

  • cerebellum

  • metanephros

  • cerebellar cortex

  • cerebellar hemisphere

  • right coronary artery
Top expressed in
  • seminiferous tubule

  • spermatid

  • spermatocyte

  • proximal tubule

  • kidney

  • ileum

  • sexually immature organism

  • lip

  • striated muscle tissue

  • skeletal muscle tissue
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • protein binding
  • molecular function
Cellular component
  • cytoplasm
  • mitochondrial membranes
  • mitochondrion
  • membrane
Biological process
  • flagellated sperm motility
  • penetration of zona pellucida
  • single fertilization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

4184

17235

Ensembl

ENSG00000163206

ENSMUSG00000074435

UniProt

P49901

P15265

RefSeq (mRNA)

NM_030663

NM_008574

RefSeq (protein)

NP_109588

NP_032600

Location (UCSC)Chr 1: 152.88 – 152.89 MbChr 3: 92.49 – 92.5 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sperm mitochondrial-associated cysteine-rich protein is a protein that in humans is encoded by the SMCP gene.[5][6]

Function

Sperm mitochondria differ in morphology and subcellular localization from those of somatic cells. They are elongated, flattened, and arranged circumferentially to form a helical coiled sheath in the midpiece of the sperm flagellum. The protein encoded by this gene localizes to the capsule associated with the mitochondrial outer membranes and is thought to function in the organization and stabilization of the helical structure of the sperm's mitochondrial sheath.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000163206 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000074435 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Aho H, Schwemmer M, Tessman D, Murphy D, Mattei G, Engel W, Adham IM (Mar 1996). "Isolation, expression, and chromosomal localization of the human mitochondrial capsule selenoprotein gene (MCSP)". Genomics. 32 (2): 184–90. doi:10.1006/geno.1996.0104. PMID 8833144.
  6. ^ a b "Entrez Gene: SMCP sperm mitochondria-associated cysteine-rich protein".

Further reading

  • Behne D, Kyriakopoulos A (2001). "Mammalian selenium-containing proteins". Annual Review of Nutrition. 21: 453–73. doi:10.1146/annurev.nutr.21.1.453. PMID 11375445.
  • Karimpour I, Cutler M, Shih D, Smith J, Kleene KC (Nov 1992). "Sequence of the gene encoding the mitochondrial capsule selenoprotein of mouse sperm: identification of three in-phase TGA selenocysteine codons". DNA and Cell Biology. 11 (9): 693–9. doi:10.1089/dna.1992.11.693. PMID 1418626.
  • Saaranen M, Suistomaa U, Vanha-Perttula T (Apr 1989). "Semen selenium content and sperm mitochondrial volume in human and some animal species". Human Reproduction. 4 (3): 304–8. doi:10.1093/oxfordjournals.humrep.a136893. PMID 2715306.
  • Cataldo L, Baig K, Oko R, Mastrangelo MA, Kleene KC (Nov 1996). "Developmental expression, intracellular localization, and selenium content of the cysteine-rich protein associated with the mitochondrial capsules of mouse sperm". Molecular Reproduction and Development. 45 (3): 320–31. doi:10.1002/(SICI)1098-2795(199611)45:3<320::AID-MRD9>3.0.CO;2-U. PMID 8916043. S2CID 10296253.
  • Herr JC, Thomas D, Bush LA, Coonrod S, Khole V, Howards SS, Flickinger CJ (Aug 1999). "Sperm mitochondria-associated cysteine-rich protein (SMCP) is an autoantigen in Lewis rats". Biology of Reproduction. 61 (2): 428–35. doi:10.1095/biolreprod61.2.428. PMID 10411523.
  • Nayernia K, Adham IM, Burkhardt-Göttges E, Neesen J, Rieche M, Wolf S, Sancken U, Kleene K, Engel W (May 2002). "Asthenozoospermia in mice with targeted deletion of the sperm mitochondrion-associated cysteine-rich protein (Smcp) gene". Molecular and Cellular Biology. 22 (9): 3046–52. doi:10.1128/MCB.22.9.3046-3052.2002. PMC 133774. PMID 11940662.
  • Hawthorne SK, Goodarzi G, Bagarova J, Gallant KE, Busanelli RR, Olend WJ, Kleene KC (Mar 2006). "Comparative genomics of the sperm mitochondria-associated cysteine-rich protein gene". Genomics. 87 (3): 382–91. doi:10.1016/j.ygeno.2005.09.010. PMID 16325371.
  • Yatsenko AN, Roy A, Chen R, Ma L, Murthy LJ, Yan W, Lamb DJ, Matzuk MM (Dec 2006). "Non-invasive genetic diagnosis of male infertility using spermatozoal RNA: KLHL10 mutations in oligozoospermic patients impair homodimerization". Human Molecular Genetics. 15 (23): 3411–9. doi:10.1093/hmg/ddl417. PMID 17047026.
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