SGIP1

Protein-coding gene in the species Homo sapiens
SGIP1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

5AWR, 5AWT, 5AWU, 5AWS

Identifiers
AliasesSGIP1, SH3 domain GRB2 like endophilin interacting protein 1, SH3GL interacting endocytic adaptor 1
External IDsOMIM: 611540; MGI: 1920344; HomoloGene: 13001; GeneCards: SGIP1; OMA:SGIP1 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for SGIP1
Genomic location for SGIP1
Band1p31.3Start66,533,267 bp[1]
End66,751,139 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for SGIP1
Genomic location for SGIP1
Band4|4 C6Start102,741,297 bp[2]
End102,973,628 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • tibial arteries

  • Descending thoracic aorta

  • ascending aorta

  • prefrontal cortex

  • middle temporal gyrus

  • Brodmann area 46

  • Brodmann area 23

  • endothelial cell

  • C1 segment
Top expressed in
  • Rostral migratory stream

  • neural layer of retina

  • superior frontal gyrus

  • substantia nigra

  • dentate gyrus of hippocampal formation granule cell

  • piriform cortex

  • medial dorsal nucleus

  • primary visual cortex

  • cerebellar cortex

  • medial geniculate nucleus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • microtubule binding
  • SH3 domain binding
  • tubulin binding
  • protein binding
  • phospholipid binding
  • cytoskeletal protein binding
Cellular component
  • cytoplasm
  • plasma membrane
  • clathrin-coated pit
  • AP-2 adaptor complex
  • membrane
  • clathrin-coated vesicle
  • cytosol
  • cytoskeleton
Biological process
  • positive regulation of receptor-mediated endocytosis
  • endocytosis
  • plasma membrane tubulation
  • membrane organization
  • response to dietary excess
  • positive regulation of feeding behavior
  • clathrin-dependent endocytosis
  • energy homeostasis
  • clathrin coat assembly
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

84251

73094

Ensembl

ENSG00000118473

ENSMUSG00000028524

UniProt

Q9BQI5

Q8VD37

RefSeq (mRNA)
NM_001308203
NM_032291
NM_001350217
NM_001350218
NM_001376534

NM_001376535
NM_001376536
NM_001376537
NM_001376538
NM_001376539
NM_001376540
NM_001376541
NM_001376542
NM_001376543
NM_001376544
NM_001376545
NM_001376546
NM_001376547
NM_001376548
NM_001376549
NM_001376550
NM_001376551
NM_001376552
NM_001376554
NM_001376555
NM_001376556
NM_001376557

NM_001285852
NM_001285859
NM_001285860
NM_001285862
NM_144906

RefSeq (protein)
NP_001295132
NP_115667
NP_001337146
NP_001337147
NP_001363463

NP_001363464
NP_001363465
NP_001363466
NP_001363467
NP_001363468
NP_001363469
NP_001363470
NP_001363471
NP_001363472
NP_001363473
NP_001363474
NP_001363475
NP_001363476
NP_001363477
NP_001363478
NP_001363479
NP_001363480
NP_001363481
NP_001363483
NP_001363484
NP_001363485
NP_001363486

NP_001272781
NP_001272788
NP_001272789
NP_001272791
NP_659155

Location (UCSC)Chr 1: 66.53 – 66.75 MbChr 4: 102.74 – 102.97 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

SH3-containing GRB2-like protein 3-interacting protein 1 is a protein that in humans is encoded by the SGIP1 gene.[5][6]


References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000118473 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028524 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
  6. ^ "Entrez Gene: SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1".

Further reading

  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
  • Simpson JC, Wellenreuther R, Poustka A, et al. (2001). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Rep. 1 (3): 287–92. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
  • Trevaskis J, Walder K, Foletta V, et al. (2005). "Src homology 3-domain growth factor receptor-bound 2-like (endophilin) interacting protein 1, a novel neuronal protein that regulates energy balance". Endocrinology. 146 (9): 3757–64. doi:10.1210/en.2005-0282. hdl:10536/DRO/DU:30009269. PMID 15919751.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
  • Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
  • Uezu A, Horiuchi A, Kanda K, et al. (2007). "SGIP1alpha is an endocytic protein that directly interacts with phospholipids and Eps15". J. Biol. Chem. 282 (36): 26481–9. doi:10.1074/jbc.M703815200. PMID 17626015.


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