SEPTIN1

Protein-coding gene in the species Homo sapiens
SEPTIN1
Identifiers
AliasesSEPTIN1, DIFF6, LARP, PNUTL3, SEP1, septin 1, SEPT1
External IDsOMIM: 612897; MGI: 1858916; HomoloGene: 23009; GeneCards: SEPTIN1; OMA:SEPTIN1 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for SEPTIN1
Genomic location for SEPTIN1
Band16p11.2Start30,378,135 bp[1]
End30,395,991 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for SEPTIN1
Genomic location for SEPTIN1
Band7|7 F3Start126,813,619 bp[2]
End126,832,302 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • granulocyte

  • appendix

  • spleen

  • lymph node

  • thymus

  • blood

  • bone marrow cells

  • mucosa of transverse colon

  • rectum

  • sural nerve
Top expressed in
  • granulocyte

  • thymus

  • ventricular zone

  • blood

  • blastocyst

  • morula

  • spleen

  • neural layer of retina

  • lymph node

  • genital tubercle
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • nucleotide binding
  • GTP binding
  • protein binding
  • identical protein binding
  • GTPase activity
  • molecular adaptor activity
Cellular component
  • cytoplasm
  • cytoskeleton
  • microtubule organizing center
  • midbody
  • septin ring
  • synaptic vesicle
  • microtubule cytoskeleton
  • septin complex
  • septin filament array
Biological process
  • cell division
  • cell cycle
  • mitotic cytokinesis
  • septin ring assembly
  • regulation of exocytosis
  • cilium assembly
  • cytoskeleton-dependent cytokinesis
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

1731

54204

Ensembl

ENSG00000180096

ENSMUSG00000000486

UniProt

Q8WYJ6

P42209

RefSeq (mRNA)

NM_052838
NM_001365977

NM_017461

RefSeq (protein)

NP_443070
NP_001352906

NP_059489

Location (UCSC)Chr 16: 30.38 – 30.4 MbChr 7: 126.81 – 126.83 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Septin-1 is a protein that in humans is encoded by the SEPTIN1 gene.[5][6] It was renamed from SEPT1 to avoid problems where Microsoft Excel would auto-correct the gene name to the date September 1.[7]

Function

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes a protein associated with the tau-based paired helical filament core, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180096 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000000486 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Mori T, Miura K, Fujiwara T, Shin S, Inazawa J, Nakamura Y (Sep 1996). "Isolation and mapping of a human gene (DIFF6) homologous to yeast CDC3, CDC10, CDC11, and CDC12, and mouse Diff6". Cytogenetics and Cell Genetics. 73 (3): 224–7. doi:10.1159/000134343. PMID 8697812.
  6. ^ a b "Entrez Gene: SEPT1 septin 1".
  7. ^ Vincent J (6 August 2020). "Scientists rename human genes to stop Microsoft Excel from misreading them as dates". the Verge. Retrieved 2022-10-24.

Further reading

  • Nottenburg C, Gallatin WM, St John T (November 1990). "Lymphocyte HEV adhesion variants differ in the expression of multiple gene sequences". Gene. 95 (2): 279–84. doi:10.1016/0378-1119(90)90372-X. PMID 2174398.
  • Kinoshita A, Kinoshita M, Akiyama H, Tomimoto H, Akiguchi I, Kumar S, Noda M, Kimura J (November 1998). "Identification of septins in neurofibrillary tangles in Alzheimer's disease". The American Journal of Pathology. 153 (5): 1551–60. doi:10.1016/S0002-9440(10)65743-4. PMC 1853406. PMID 9811347.
  • Scanlan MJ, Gout I, Gordon CM, Williamson B, Stockert E, Gure AO, Jäger D, Chen YT, Mackay A, O'Hare MJ, Old LJ (March 2001). "Humoral immunity to human breast cancer: antigen definition and quantitative analysis of mRNA expression". Cancer Immunity. 1: 4. PMID 12747765.
  • Qi M, Yu W, Liu S, Jia H, Tang L, Shen M, Yan X, Saiyin H, Lang Q, Wan B, Zhao S, Yu L (October 2005). "Septin1, a new interaction partner for human serine/threonine kinase aurora-B". Biochemical and Biophysical Research Communications. 336 (3): 994–1000. doi:10.1016/j.bbrc.2005.06.212. PMID 16179162.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kato Y, Uzawa K, Yamamoto N, Kouzu Y, Koike H, Shiiba M, Bukawa H, Yokoe H, Shibahara T, Tanzawa H (November 2007). "Overexpression of Septin1: possible contribution to the development of oral cancer". International Journal of Oncology. 31 (5): 1021–8. doi:10.3892/ijo.31.5.1021. PMID 17912427.
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