SALL2

Protein-coding gene in the species Homo sapiens
SALL2
Identifiers
AliasesSALL2, COLB, HSAL2, Sal-2, ZNF795, p150(Sal2), spalt-like transcription factor 2, spalt like transcription factor 2
External IDsOMIM: 602219; MGI: 1354373; HomoloGene: 9269; GeneCards: SALL2; OMA:SALL2 - orthologs
Gene location (Human)
Chromosome 14 (human)
Chr.Chromosome 14 (human)[1]
Chromosome 14 (human)
Genomic location for SALL2
Genomic location for SALL2
Band14q11.2Start21,521,080 bp[1]
End21,537,216 bp[1]
Gene location (Mouse)
Chromosome 14 (mouse)
Chr.Chromosome 14 (mouse)[2]
Chromosome 14 (mouse)
Genomic location for SALL2
Genomic location for SALL2
Band14|14 C2Start52,548,629 bp[2]
End52,566,219 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar vermis

  • superior vestibular nucleus

  • ventral tegmental area

  • inferior olivary nucleus

  • pons

  • oocyte

  • hypothalamus

  • embryo

  • optic nerve

  • subthalamic nucleus
Top expressed in
  • saccule

  • dorsomedial hypothalamic nucleus

  • otic placode

  • median eminence

  • supraoptic nucleus

  • inferior colliculus

  • habenula

  • arcuate nucleus

  • ventromedial nucleus

  • paraventricular nucleus of hypothalamus
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA-binding transcription factor activity
  • sequence-specific DNA binding
  • DNA binding
  • protein binding
  • metal ion binding
  • nucleic acid binding
  • RNA polymerase II transcription regulatory region sequence-specific DNA binding
  • DNA-binding transcription activator activity, RNA polymerase II-specific
  • DNA-binding transcription factor activity, RNA polymerase II-specific
  • protein-containing complex binding
Cellular component
  • NuRD complex
  • nucleus
Biological process
  • eye development
  • negative regulation of transcription, DNA-templated
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription by RNA polymerase II
  • neural tube development
  • signal transduction
  • transcription, DNA-templated
  • positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

6297

50524

Ensembl

ENSG00000165821

ENSMUSG00000049532

UniProt

Q9Y467

Q9QX96

RefSeq (mRNA)

NM_001291446
NM_001291447
NM_005407
NM_001364564

NM_001244916
NM_015772

RefSeq (protein)

NP_001278375
NP_001278376
NP_005398
NP_001351493

NP_001231845
NP_056587

Location (UCSC)Chr 14: 21.52 – 21.54 MbChr 14: 52.55 – 52.57 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Sal-like protein 2 is a protein that in humans is encoded by the SALL2 gene.[5][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000165821 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049532 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Kohlhase J, Schuh R, Dowe G, Kühnlein RP, Jäckle H, Schroeder B, Schulz-Schaeffer W, Kretzschmar HA, Köhler A, Müller U, Raab-Vetter M, Burkhardt E, Engel W, Stick R (December 1996). "Isolation, characterization, and organ-specific expression of two novel human zinc finger genes related to the Drosophila gene spalt". Genomics. 38 (3): 291–8. doi:10.1006/geno.1996.0631. PMID 8975705.
  6. ^ "Entrez Gene: SALL2 sal-like 2 (Drosophila)".

Further reading

  • Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
  • Sweetman D, Münsterberg A (May 2006). "The vertebrate spalt genes in development and disease" (PDF). Developmental Biology. 293 (2): 285–93. doi:10.1016/j.ydbio.2006.02.009. PMID 16545361. S2CID 45268563.
  • Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Nagase T, Ishikawa K, Nakajima D, Ohira M, Seki N, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (April 1997). "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 4 (2): 141–50. doi:10.1093/dnares/4.2.141. PMID 9205841.
  • Nielsen TO, Hsu FD, O'Connell JX, Gilks CB, Sorensen PH, Linn S, West RB, Liu CL, Botstein D, Brown PO, van de Rijn M (October 2003). "Tissue microarray validation of epidermal growth factor receptor and SALL2 in synovial sarcoma with comparison to tumors of similar histology". The American Journal of Pathology. 163 (4): 1449–56. doi:10.1016/S0002-9440(10)63502-X. PMC 1868308. PMID 14507652.
  • Li D, Tian Y, Ma Y, Benjamin T (May 2004). "p150(Sal2) is a p53-independent regulator of p21(WAF1/CIP)". Molecular and Cellular Biology. 24 (9): 3885–93. doi:10.1128/MCB.24.9.3885-3893.2004. PMC 387742. PMID 15082782.
  • v
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(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
(1.2) Basic helix-loop-helix (bHLH)
Group A
Group B
Group C
bHLH-PAS
Group D
Group E
Group F
bHLH-COE
(1.3) bHLH-ZIP
(1.4) NF-1
(1.5) RF-X
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1
subfamily 2
subfamily 3
subfamily 4
subfamily 5
subfamily 6
subfamily 0
(2.2) Other Cys4
(2.3) Cys2His2
(2.4) Cys6
(2.5) Alternating composition
(2.6) WRKY
(3) Helix-turn-helix domains
(3.1) Homeodomain
Antennapedia
ANTP class
protoHOX
Hox-like
metaHOX
NK-like
other
(3.2) Paired box
(3.3) Fork head / winged helix
(3.4) Heat shock factors
(3.5) Tryptophan clusters
(3.6) TEA domain
  • transcriptional enhancer factor
(4) β-Scaffold factors with minor groove contacts
(4.1) Rel homology region
(4.2) STAT
(4.3) p53-like
(4.4) MADS box
(4.6) TATA-binding proteins
(4.7) High-mobility group
(4.9) Grainyhead
(4.10) Cold-shock domain
(4.11) Runt
(0) Other transcription factors
(0.2) HMGI(Y)
(0.3) Pocket domain
(0.5) AP-2/EREBP-related factors
(0.6) Miscellaneous
see also transcription factor/coregulator deficiencies
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