RNF11

Protein-coding gene in the species Homo sapiens
RNF11
Identifiers
AliasesRNF11, SID1669, CGI-123, ring finger protein 11
External IDsOMIM: 612598; MGI: 1352759; HomoloGene: 32195; GeneCards: RNF11; OMA:RNF11 - orthologs
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for RNF11
Genomic location for RNF11
Band1p32.3Start51,236,273 bp[1]
End51,273,447 bp[1]
Gene location (Mouse)
Chromosome 4 (mouse)
Chr.Chromosome 4 (mouse)[2]
Chromosome 4 (mouse)
Genomic location for RNF11
Genomic location for RNF11
Band4|4 C7Start109,308,295 bp[2]
End109,341,925 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • lateral nuclear group of thalamus

  • endothelial cell

  • prefrontal cortex

  • Pars compacta

  • external globus pallidus

  • pars reticulata

  • dorsolateral prefrontal cortex

  • superior vestibular nucleus

  • monocyte

  • Brodmann area 9
Top expressed in
  • blood

  • lateral septal nucleus

  • tibiofemoral joint

  • cardiac muscle tissue of left ventricle

  • ventromedial nucleus

  • cingulate gyrus

  • CA3 field

  • perirhinal cortex

  • subcutaneous adipose tissue

  • central gray substance of midbrain
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • protein binding
  • metal ion binding
  • ubiquitin-protein transferase activity
  • ubiquitin protein ligase activity
  • zinc ion binding
Cellular component
  • ubiquitin ligase complex
  • cytoplasm
  • recycling endosome
  • endosome
  • early endosome
  • extracellular exosome
  • nucleus
Biological process
  • ubiquitin-dependent protein catabolic process
  • protein autoubiquitination
  • proteasome-mediated ubiquitin-dependent protein catabolic process
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

26994

29864

Ensembl

ENSG00000123091

ENSMUSG00000028557

UniProt

Q9Y3C5

Q9QYK7

RefSeq (mRNA)

NM_014372

NM_013876

RefSeq (protein)

NP_055187

NP_038904

Location (UCSC)Chr 1: 51.24 – 51.27 MbChr 4: 109.31 – 109.34 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

RING finger protein 11 is a protein that in humans is encoded by the RNF11 gene.[5][6][7]

Function

The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN).[7]

See also

Interactions

RNF11 has been shown to interact with RIPK1[8] and STAMBP.[9]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000123091 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028557 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Seki N, Hattori A, Hayashi A, Kozuma S, Sasaki M, Suzuki Y, Sugano S, Muramatsu MA, Saito T (December 1999). "Cloning and expression profile of mouse and human genes, Rnf11/RNF11, encoding a novel RING-H2 finger protein". Biochim. Biophys. Acta. 1489 (2–3): 421–7. doi:10.1016/s0167-4781(99)00190-6. PMID 10673045.
  6. ^ Lai CH, Chou CY, Ch'ang LY, Liu CS, Lin W (August 2000). "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics". Genome Res. 10 (5): 703–13. doi:10.1101/gr.10.5.703. PMC 310876. PMID 10810093.
  7. ^ a b "Entrez Gene: RNF11 ring finger protein 11".
  8. ^ Shembade N, Parvatiyar K, Harhaj NS, Harhaj EW (March 2009). "The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling". EMBO J. 28 (5): 513–22. doi:10.1038/emboj.2008.285. PMC 2657574. PMID 19131965.
  9. ^ Li H, Seth A (March 2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. S2CID 37253372.

Further reading

  • Burger A, Amemiya Y, Kitching R, Seth AK (2006). "Novel RING E3 ubiquitin ligases in breast cancer". Neoplasia. 8 (8): 689–95. doi:10.1593/neo.06469. PMC 1601945. PMID 16925951.
  • Jolliffe CN, Harvey KF, Haines BP, Parasivam G, Kumar S (2000). "Identification of multiple proteins expressed in murine embryos as binding partners for the WW domains of the ubiquitin-protein ligase Nedd4". Biochem. J. 351 Pt 3 (3): 557–65. doi:10.1042/0264-6021:3510557. PMC 1221394. PMID 11042109.
  • Watanabe T, Ichihara M, Hashimoto M, Shimono K, Shimoyama Y, Nagasaka T, Murakumo Y, Murakami H, Sugiura H, Iwata H, Ishiguro N, Takahashi M (2002). "Characterization of gene expression induced by RET with MEN2A or MEN2B mutation". Am. J. Pathol. 161 (1): 249–56. doi:10.1016/S0002-9440(10)64176-4. PMC 1850689. PMID 12107109.
  • Kitching R, Wong MJ, Koehler D, Burger AM, Landberg G, Gish G, Seth A (2003). "The RING-H2 protein RNF11 is differentially expressed in breast tumours and interacts with HECT-type E3 ligases". Biochim. Biophys. Acta. 1639 (2): 104–12. doi:10.1016/j.bbadis.2003.07.001. PMID 14559117.
  • Subramaniam V, Li H, Wong M, Kitching R, Attisano L, Wrana J, Zubovits J, Burger AM, Seth A (2003). "The RING-H2 protein RNF11 is overexpressed in breast cancer and is a target of Smurf2 E3 ligase". Br. J. Cancer. 89 (8): 1538–44. doi:10.1038/sj.bjc.6601301. PMC 2394340. PMID 14562029.
  • Li H, Seth A (2004). "An RNF11: Smurf2 complex mediates ubiquitination of the AMSH protein". Oncogene. 23 (10): 1801–8. doi:10.1038/sj.onc.1207319. PMID 14755250. S2CID 37253372.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
  • Connor MK, Azmi PB, Subramaniam V, Li H, Seth A (2005). "Molecular characterization of ring finger protein 11". Mol. Cancer Res. 3 (8): 453–61. doi:10.1158/1541-7786.MCR-04-0166. PMID 16123141. S2CID 24739627.
  • Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Anderson LR, Betarbet R, Gearing M, Gulcher J, Hicks AA, Stefánsson K, Lah JJ, Levey AI (2007). "PARK10 candidate RNF11 is expressed by vulnerable neurons and localizes to Lewy bodies in Parkinson disease brain". J. Neuropathol. Exp. Neurol. 66 (10): 955–64. doi:10.1097/nen.0b013e3181567f17. PMID 17917589.

External links


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