PRMT6

Protein-coding gene in the species Homo sapiens
PRMT6
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4HC4, 4QPP, 4QQK, 4Y2H, 4Y30, 5EGS, 5E8R, 5HZM

Identifiers
AliasesPRMT6, HRMT1L6, protein arginine methyltransferase 6
External IDsOMIM: 608274; MGI: 2139971; HomoloGene: 10024; GeneCards: PRMT6; OMA:PRMT6 - orthologs
EC number2.1.1.321
Gene location (Human)
Chromosome 1 (human)
Chr.Chromosome 1 (human)[1]
Chromosome 1 (human)
Genomic location for PRMT6
Genomic location for PRMT6
Band1p13.3Start107,056,674 bp[1]
End107,067,636 bp[1]
Gene location (Mouse)
Chromosome 3 (mouse)
Chr.Chromosome 3 (mouse)[2]
Chromosome 3 (mouse)
Genomic location for PRMT6
Genomic location for PRMT6
Band3|3 F3Start110,153,425 bp[2]
End110,158,314 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • gonad

  • islet of Langerhans

  • palpebral conjunctiva

  • right adrenal cortex

  • mucosa of sigmoid colon

  • metanephros

  • testicle

  • left adrenal gland

  • left adrenal cortex

  • prefrontal cortex
Top expressed in
  • renal corpuscle

  • medullary collecting duct

  • spermatocyte

  • endocardial cushion

  • epiblast

  • embryo

  • primitive streak

  • yolk sac

  • tail of embryo

  • right kidney
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • methyltransferase activity
  • transferase activity
  • histone methyltransferase activity
  • protein-arginine omega-N monomethyltransferase activity
  • histone methyltransferase activity (H4-R3 specific)
  • histone binding
  • protein-arginine omega-N asymmetric methyltransferase activity
  • chromatin binding
  • histone methyltransferase activity (H2A-R3 specific)
  • histone methyltransferase activity (H3-R2 specific)
  • protein binding
  • protein-arginine N-methyltransferase activity
  • histone-arginine N-methyltransferase activity
Cellular component
  • nucleoplasm
  • nucleus
  • nucleolus
  • cytosol
Biological process
  • regulation of transcription, DNA-templated
  • negative regulation of transcription by RNA polymerase II
  • transcription, DNA-templated
  • cellular response to DNA damage stimulus
  • cellular senescence
  • methylation
  • peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
  • histone methylation
  • viral process
  • negative regulation of transcription, DNA-templated
  • DNA repair
  • base-excision repair
  • protein methylation
  • histone H4-R3 methylation
  • regulation of megakaryocyte differentiation
  • chromatin organization
  • histone H3-R2 methylation
  • peptidyl-arginine N-methylation
  • negative regulation of histone H3-K4 methylation
  • regulation of signal transduction by p53 class mediator
  • histone arginine methylation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55170

99890

Ensembl

ENSG00000198890

ENSMUSG00000049300

UniProt

Q96LA8

Q6NZB1

RefSeq (mRNA)

NM_018137

NM_178891

RefSeq (protein)

NP_060607

NP_849222

Location (UCSC)Chr 1: 107.06 – 107.07 MbChr 3: 110.15 – 110.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Protein arginine N-methyltransferase 6 is an enzyme that in humans is encoded by the PRMT6 gene.[5][6]

Protein arginine N-methyltransferases, such as PRMT6, catalyze the sequential transfer of a methyl group from S-adenosyl-L-methionine to the side chain nitrogens of arginine residues within proteins to form methylated arginine derivatives and S-adenosyl-L-homocysteine.[supplied by OMIM][6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000198890 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000049300 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S, Bedford MT (Jan 2002). "The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity". J Biol Chem. 277 (5): 3537–43. doi:10.1074/jbc.M108786200. PMID 11724789.
  6. ^ a b "Entrez Gene: PRMT6 protein arginine methyltransferase 6".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Boulanger MC, Liang C, Russell RS, et al. (2005). "Methylation of Tat by PRMT6 Regulates Human Immunodeficiency Virus Type 1 Gene Expression". J. Virol. 79 (1): 124–31. doi:10.1128/JVI.79.1.124-131.2005. PMC 538702. PMID 15596808.
  • Sgarra R, Lee J, Tessari MA, et al. (2006). "The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6". J. Biol. Chem. 281 (7): 3764–72. doi:10.1074/jbc.M510231200. hdl:11577/1565364. PMID 16293633.
  • Willemsen NM, Hitchen EM, Bodetti TJ, et al. (2007). "Protein methylation is required to maintain optimal HIV-1 infectivity". Retrovirology. 3: 92. doi:10.1186/1742-4690-3-92. PMC 1766367. PMID 17169163.
  • Invernizzi CF, Xie B, Richard S, Wainberg MA (2007). "PRMT6 diminishes HIV-1 Rev binding to and export of viral RNA". Retrovirology. 3: 93. doi:10.1186/1742-4690-3-93. PMC 1779295. PMID 17176473.
  • Xie B, Invernizzi CF, Richard S, Wainberg MA (2007). "Arginine Methylation of the Human Immunodeficiency Virus Type 1 Tat Protein by PRMT6 Negatively Affects Tat Interactions with both Cyclin T1 and the Tat Transactivation Region". J. Virol. 81 (8): 4226–34. doi:10.1128/JVI.01888-06. PMC 1866113. PMID 17267505.
  • Guccione E, Bassi C, Casadio F, et al. (2007). "Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive". Nature. 449 (7164): 933–7. Bibcode:2007Natur.449..933G. doi:10.1038/nature06166. PMID 17898714. S2CID 4341782.


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