POLR2I

Protein-coding gene in the species Homo sapiens

POLR2I

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
5IYD, 5IY8, 5IY6, 5IYA, 5IYC, 5IY7, 5IY9, 5IYB

Identifiers

Aliases

POLR2I, RPB9, hRPB14.5, polymerase (RNA) II subunit I, RNA polymerase II subunit I

External IDs

OMIM: 180662; MGI: 1917170; HomoloGene: 4541; GeneCards: POLR2I; OMA:POLR2I - orthologs

Gene location (Human)

Chr.	Chromosome 19 (human)^[1]

Band	19q13.12	Start	36,113,709 bp^[1]
Band	19q13.12	End	36,115,213 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 7 (mouse)^[2]

Band	7\|7 B1	Start	29,931,373 bp^[2]
Band	7\|7 B1	End	29,932,815 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

nucleus accumbens

amygdala

putamen

gastrocnemius muscle

caudate nucleus

prefrontal cortex

Brodmann area 9

right uterine tube

hypothalamus

cingulate gyrus

Top expressed in

internal carotid artery

medial ganglionic eminence

external carotid artery

triceps brachii muscle

sternocleidomastoid muscle

fossa

condyle

neural tube

maxillary prominence

temporal muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	zinc ion binding metal ion binding nucleic acid binding DNA-directed 5'-3' RNA polymerase activity
Cellular component	nucleolus RNA polymerase II, core complex nucleus nucleoplasm
Biological process	mRNA splicing, via spliceosome transcription elongation from RNA polymerase II promoter 7-methylguanosine mRNA capping transcription by RNA polymerase II snRNA transcription by RNA polymerase II fibroblast growth factor receptor signaling pathway mRNA cleavage RNA metabolic process regulation of gene silencing by miRNA maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter transcription-coupled nucleotide-excision repair transcription initiation from RNA polymerase II promoter transcription, DNA-templated somatic stem cell population maintenance positive regulation of viral transcription
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


5438


69920

Ensembl


ENSG00000105258


ENSMUSG00000019738

UniProt


P36954


P60898

RefSeq (mRNA)


NM_006233


NM_027259

RefSeq (protein)


NP_006224


NP_081535

Location (UCSC)

Chr 19: 36.11 – 36.12 Mb

Chr 7: 29.93 – 29.93 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

DNA-directed RNA polymerase II subunit RPB9 is an enzyme that in humans is encoded by the POLR2I gene.^[5]

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This subunit, in combination with two other polymerase subunits, forms the DNA binding domain of the polymerase, a groove in which the DNA template is transcribed into RNA. The product of this gene has two zinc finger motifs with conserved cysteines and the subunit does possess zinc binding activity.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000105258 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000019738 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Acker J, Mattei MG, Wintzerith M, Roeckel N, Depetris D, Vigneron M, Kedinger C (Aug 1994). "Chromosomal localization of human RNA polymerase II subunit genes". Genomics. 20 (3): 496–9. doi:10.1006/geno.1994.1208. PMID 8034326.
^ "Entrez Gene: POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa".

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