MYLPF

Protein-coding gene in the species Homo sapiens
MYL11
Identifiers
AliasesMYL11, MYLPF, myosin light chain 11, HUMMLC2B, MLC2B, myosin light chain, phosphorylatable, fast skeletal muscle, MRLC2, DA1C
External IDsOMIM: 617378; MGI: 97273; HomoloGene: 22728; GeneCards: MYL11; OMA:MYL11 - orthologs
Gene location (Human)
Chromosome 16 (human)
Chr.Chromosome 16 (human)[1]
Chromosome 16 (human)
Genomic location for MYL11
Genomic location for MYL11
Band16p11.2Start30,370,934 bp[1]
End30,377,991 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for MYL11
Genomic location for MYL11
Band7|7 F3Start126,808,062 bp[2]
End126,813,470 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • biceps brachii

  • Skeletal muscle tissue of biceps brachii

  • Skeletal muscle tissue of rectus abdominis

  • triceps brachii muscle

  • muscle of thigh

  • gastrocnemius muscle

  • vastus lateralis muscle

  • glutes

  • thoracic diaphragm

  • body of tongue
Top expressed in
  • temporal muscle

  • sternocleidomastoid muscle

  • triceps brachii muscle

  • digastric muscle

  • medial head of gastrocnemius muscle

  • muscle of thigh

  • vastus lateralis muscle

  • body of femur

  • intercostal muscle

  • ankle
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • calcium ion binding
  • structural constituent of muscle
  • metal ion binding
Cellular component
  • lysosomal membrane
  • cytosol
  • muscle myosin complex
  • myosin complex
Biological process
  • muscle contraction
  • skeletal muscle tissue development
  • immune response
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

29895

17907

Ensembl

ENSG00000180209

ENSMUSG00000030672

UniProt

Q96A32

P97457

RefSeq (mRNA)

NM_013292
NM_001324458
NM_001324459

NM_016754
NM_001347655

RefSeq (protein)

NP_001311387
NP_001311388
NP_037424

NP_001334584
NP_058034

Location (UCSC)Chr 16: 30.37 – 30.38 MbChr 7: 126.81 – 126.81 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Myosin light chain, phosphorylatable, fast skeletal muscle is a protein that in humans is encoded by the MYLPF gene.[5] It is located on chromosome 16 in humans. Myosin light chain, phosphorylatable

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000180209 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030672 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ "Entrez Gene: Myosin light chain, phosphorylatable, fast skeletal muscle".

Further reading

  • Nudel U, Calvo JM, Shani M, Levy Z (Sep 1984). "The nucleotide sequence of a rat myosin light chain 2 gene". Nucleic Acids Research. 12 (18): 7175–86. doi:10.1093/nar/12.18.7175. PMC 320149. PMID 6091059.
  • Garfinkel LI, Periasamy M, Nadal-Ginard B (Sep 1982). "Cloning and characterization of cDNA sequences corresponding to myosin light chains 1, 2, and 3, troponin-C, troponin-T, alpha-tropomyosin, and alpha-actin". The Journal of Biological Chemistry. 257 (18): 11078–86. doi:10.1016/S0021-9258(18)33935-8. PMID 6179945.
  • Sachdev S, Raychowdhury MK, Sarkar S (Oct 2003). "Human fast skeletal myosin light chain 2 cDNA: isolation, tissue specific expression of the single copy gene, comparative sequence analysis of isoforms and evolutionary relationships". DNA Sequence. 14 (5): 339–50. doi:10.1080/1042517031000154952. PMID 14756420. S2CID 7284166.
  • Amoresano A, Di Costanzo A, Leo G, Di Cunto F, La Mantia G, Guerrini L, Calabrò V (Apr 2010). "Identification of DeltaNp63alpha protein interactions by mass spectrometry". Journal of Proteome Research. 9 (4): 2042–8. doi:10.1021/pr9011156. PMID 20085233.


  • v
  • t
  • e