MAP1S

Protein-coding gene in the species Homo sapiens
MAP1S
Identifiers
AliasesMAP1S, BPY2IP1, C19orf5, MAP8, VCY2IP-1, VCY2IP1, microtubule associated protein 1S
External IDsOMIM: 607573; MGI: 2443304; HomoloGene: 10047; GeneCards: MAP1S; OMA:MAP1S - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for MAP1S
Genomic location for MAP1S
Band19p13.11Start17,719,242 bp[1]
End17,734,513 bp[1]
Gene location (Mouse)
Chromosome 8 (mouse)
Chr.Chromosome 8 (mouse)[2]
Chromosome 8 (mouse)
Genomic location for MAP1S
Genomic location for MAP1S
Band8|8 B3.3Start71,358,576 bp[2]
End71,370,173 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right testis

  • left testis

  • prefrontal cortex

  • right frontal lobe

  • Brodmann area 9

  • anterior cingulate cortex

  • stromal cell of endometrium

  • muscle of thigh

  • putamen

  • gonad
Top expressed in
  • yolk sac

  • Rostral migratory stream

  • neural layer of retina

  • superior frontal gyrus

  • internal carotid artery

  • ankle joint

  • dentate gyrus of hippocampal formation granule cell

  • primary visual cortex

  • perirhinal cortex

  • entorhinal cortex
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • DNA binding
  • deoxyribonuclease activity
  • microtubule binding
  • tubulin binding
  • actin filament binding
  • protein binding
  • beta-tubulin binding
  • identical protein binding
  • actin binding
Cellular component
  • cytosol
  • cell projection
  • microtubule cytoskeleton
  • spindle
  • synapse
  • cell junction
  • neuronal cell body
  • dendrite
  • nucleolus
  • perinuclear region of cytoplasm
  • microtubule
  • cytoskeleton
  • nucleus
  • cytoplasm
  • microtubule associated complex
Biological process
  • neuron projection morphogenesis
  • nervous system development
  • autophagy
  • brain development
  • microtubule bundle formation
  • mitochondrion transport along microtubule
  • microtubule cytoskeleton organization
  • apoptotic process
  • DNA metabolic process
  • axonogenesis
  • dendrite development
  • regulation of microtubule depolymerization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

55201

270058

Ensembl

ENSG00000130479

ENSMUSG00000019261

UniProt

Q66K74

Q8C052

RefSeq (mRNA)

NM_001308363
NM_018174

NM_173013

RefSeq (protein)

NP_001295292
NP_060644

NP_766601

Location (UCSC)Chr 19: 17.72 – 17.73 MbChr 8: 71.36 – 71.37 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Microtubule-associated protein 1S is a protein that in humans is encoded by the MAP1S gene.[5][6][7][8][9]

Interactions

MAP1S has been shown to interact with RASSF1.[10][11]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000130479 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019261 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Liu L, McKeehan WL (Feb 2002). "Sequence analysis of LRPPRC and its SEC1 domain interaction partners suggests roles in cytoskeletal organization, vesicular trafficking, nucleocytosolic shuttling, and chromosome activity". Genomics. 79 (1): 124–36. doi:10.1006/geno.2001.6679. PMC 3241999. PMID 11827465.
  6. ^ Orbán-Németh Z, Simader H, Badurek S, Tranciková A, Propst F (Jan 2005). "Microtubule-associated protein 1S, a short and ubiquitously expressed member of the microtubule-associated protein 1 family". J. Biol. Chem. 280 (3): 2257–65. doi:10.1074/jbc.M408984200. PMID 15528209.
  7. ^ Ding J, Valle A, Allen E, Wang W, Nardine T, Zhang Y, Peng L, Yang Y (January 2006). "Microtubule-associated protein 8 contains two microtubule binding sites". Biochem. Biophys. Res. Commun. 339 (1): 172–9. doi:10.1016/j.bbrc.2005.10.199. PMID 16297881.
  8. ^ Wong EY, Tse JY, Yao KM, Lui VC, Tam PC, Yeung WS (Feb 2004). "Identification and characterization of human VCY2-interacting protein: VCY2IP-1, a microtubule-associated protein-like protein". Biol. Reprod. 70 (3): 775–84. doi:10.1095/biolreprod.103.018531. PMID 14627543.
  9. ^ "Entrez Gene: MAP1S microtubule-associated protein 1S".
  10. ^ Liu L, Vo A, McKeehan WL (Mar 2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Res. 65 (5): 1830–8. doi:10.1158/0008-5472.CAN-04-3896. PMID 15753381.
  11. ^ Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (Jun 2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.

Further reading

  • Liu L, Amy V, Liu G, McKeehan WL (2003). "Novel complex integrating mitochondria and the microtubular cytoskeleton with chromosome remodeling and tumor suppressor RASSF1 deduced by in silico homology analysis, interaction cloning in yeast, and colocalization in cultured cells". In Vitro Cell. Dev. Biol. Anim. 38 (10): 582–94. doi:10.1290/1543-706X(2002)38<582:NCIMAT>2.0.CO;2. PMC 3225227. PMID 12762840.
  • Dallol A, Agathanggelou A, Fenton SL, Ahmed-Choudhury J, Hesson L, Vos MD, Clark GJ, Downward J, Maher ER, Latif F (2004). "RASSF1A interacts with microtubule-associated proteins and modulates microtubule dynamics". Cancer Res. 64 (12): 4112–6. doi:10.1158/0008-5472.CAN-04-0267. PMID 15205320.
  • Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
  • Liu L, Vo A, McKeehan WL (2005). "Specificity of the methylation-suppressed A isoform of candidate tumor suppressor RASSF1 for microtubule hyperstabilization is determined by cell death inducer C19ORF5". Cancer Res. 65 (5): 1830–8. doi:10.1158/0008-5472.CAN-04-3896. PMID 15753381.
  • Liu L, Vo A, Liu G, McKeehan WL (2005). "Putative tumor suppressor RASSF1 interactive protein and cell death inducer C19ORF5 is a DNA binding protein". Biochem. Biophys. Res. Commun. 332 (3): 670–6. doi:10.1016/j.bbrc.2005.05.006. PMC 3225229. PMID 15907802.
  • Foster LJ, Rudich A, Talior I, Patel N, Huang X, Furtado LM, Bilan PJ, Mann M, Klip A (2006). "Insulin-dependent interactions of proteins with GLUT4 revealed through stable isotope labeling by amino acids in cell culture (SILAC)". J. Proteome Res. 5 (1): 64–75. doi:10.1021/pr0502626. PMID 16396496.


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