Filociclovir

Chemical compound
  • US: Investigational New Drug
Identifiers
  • 2-amino-9-[(Z)-[2,2-bis(hydroxymethyl)cyclopropylidene]methyl]-1H-purin-6-one
CAS Number
  • 632325-71-4
PubChem CID
  • 135409256
ChemSpider
  • 2276035
UNII
  • EAO0TD9B13
KEGG
  • D10632
CompTox Dashboard (EPA)
  • DTXSID10212612 Edit this at Wikidata
Chemical and physical dataFormulaC11H13N5O3Molar mass263.257 g·mol−13D model (JSmol)
  • Interactive image
  • C1/C(=C/N2C=NC3=C2N=C(NC3=O)N)/C1(CO)CO
InChI
  • InChI=1S/C11H13N5O3/c12-10-14-8-7(9(19)15-10)13-5-16(8)2-6-1-11(6,3-17)4-18/h2,5,17-18H,1,3-4H2,(H3,12,14,15,19)/b6-2-
  • Key:KMUNHOKTIVSFRA-KXFIGUGUSA-N

Filociclovir (cyclopropavir, MBX-400) is an antiviral drug which was developed for the treatment of cytomegalovirus infection and also shows some activity against other double-stranded DNA viruses. It has reached Phase II human clinical trials.[1][2][3]

References

  1. ^ Chemaly RF, Hill JA, Voigt S, Peggs KS (March 2019). "In vitro comparison of currently available and investigational antiviral agents against pathogenic human double-stranded DNA viruses: A systematic literature review". Antiviral Research. 163: 50–58. doi:10.1016/j.antiviral.2019.01.008. PMID 30677427.
  2. ^ Rouphael NG, Hurwitz SJ, Hart M, Beck A, Anderson EJ, Deye G, et al. (September 2019). "Phase Ib Trial To Evaluate the Safety and Pharmacokinetics of Multiple Ascending Doses of Filociclovir (MBX-400, Cyclopropavir) in Healthy Volunteers". Antimicrobial Agents and Chemotherapy. 63 (9): e00717–19. doi:10.1128/AAC.00717-19. PMC 6709474. PMID 31285228.
  3. ^ Hussein IT, Brooks J, Bowlin TL (January 2020). "The discovery and development of filociclovir for the prevention and treatment of human cytomegalovirus-related disease". Antiviral Research. 176: 104710. doi:10.1016/j.antiviral.2020.104710. PMID 31940473. S2CID 210333445.
  • v
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DNA virus antivirals (primarily J05, also S01AD and D06BB)
Baltimore I
Herpesvirus
DNA-synthesis
inhibitor
TK activated
Purine analogue
Pyrimidine analogue
Not TK activated
Other
HPV/MC
Vaccinia
Poxviridae
Hepatitis B (VII)Multiple/general
Nucleic acid inhibitors
Interferon
Multiple/unknown
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