FHL5

Protein-coding gene in the species Homo sapiens

FHL5

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1X68

Identifiers

Aliases

FHL5, ACT, dJ393D12.2, 1700027G07Rik, FHL-5, four and a half LIM domains 5

External IDs

OMIM: 605126; MGI: 1913192; HomoloGene: 23230; GeneCards: FHL5; OMA:FHL5 - orthologs

Gene location (Human)

Chr.	Chromosome 6 (human)^[1]

Band	6q16.1	Start	96,562,548 bp^[1]
Band	6q16.1	End	96,618,626 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 A3	Start	25,199,908 bp^[2]
Band	4\|4 A3	End	25,242,876 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

popliteal artery

tibial arteries

right coronary artery

sperm

left coronary artery

right testis

left testis

pericardium

Achilles tendon

Descending thoracic aorta

Top expressed in

seminiferous tubule

spermatid

spermatocyte

male urethra

muscle of thigh

secondary oocyte

esophagus

zygote

primary oocyte

skeletal muscle tissue

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transcription coactivator activity protein binding metal ion binding
Cellular component	nucleus Z disc
Biological process	positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9457


57756

Ensembl


ENSG00000112214


ENSMUSG00000028259

UniProt


Q5TD97


Q9WTX7

RefSeq (mRNA)


NM_001170807 NM_020482 NM_001322466 NM_001322467


NM_021318 NM_001355498 NM_001379528

RefSeq (protein)


NP_001164278 NP_001309395 NP_001309396 NP_065228


NP_067293 NP_001342427 NP_001366457

Location (UCSC)

Chr 6: 96.56 – 96.62 Mb

Chr 4: 25.2 – 25.24 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Four and a half LIM domains protein 5 is a protein that in humans is encoded by the FHL5 gene.^[5]

Function

The protein encoded by this gene is coordinately expressed with activator of cAMP-responsive element modulator (CREM). It is associated with CREM and confers a powerful transcriptional activation function. CREM acts as a transcription factor essential for the differentiation of spermatids into mature spermatozoa. There are multiple polyadenylation sites found in this gene.^[5]

Interactions

FHL5 has been shown to interact with CREB1^[6] and CAMP responsive element modulator.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000112214 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000028259 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: FHL5 four and a half LIM domains 5".
^ ^a ^b Fimia GM, De Cesare D, Sassone-Corsi P (November 2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166. PMID 11046156.
^ Fimia GM, De Cesare D, Sassone-Corsi P (March 1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature. 398 (6723): 165–9. Bibcode:1999Natur.398..165F. doi:10.1038/18237. PMID 10086359. S2CID 4424908.

Fimia GM, Morlon A, Macho B, De Cesare D, Sassone-Corsi P (2001). "Transcriptional cascades during spermatogenesis: pivotal role of CREM and ACT". Mol. Cell. Endocrinol. 179 (1–2): 17–23. doi:10.1016/S0303-7207(01)00463-4. PMID 11420126. S2CID 34999951.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Fimia GM, De Cesare D, Sassone-Corsi P (1999). "CBP-independent activation of CREM and CREB by the LIM-only protein ACT". Nature. 398 (6723): 165–9. Bibcode:1999Natur.398..165F. doi:10.1038/18237. PMID 10086359. S2CID 4424908.
Fimia GM, De Cesare D, Sassone-Corsi P (2000). "A family of LIM-only transcriptional coactivators: tissue-specific expression and selective activation of CREB and CREM". Mol. Cell. Biol. 20 (22): 8613–22. doi:10.1128/MCB.20.22.8613-8622.2000. PMC 102166. PMID 11046156.
Palermo I, Litrico L, Emmanuele G, Giuffrida V, Sassone-Corsi P, De Cesare D, Maria Fimia G, D'Agata R, Calogero AE, Travali S (2001). "Cloning and expression of activator of CREM in testis in human testicular tissue". Biochem. Biophys. Res. Commun. 283 (2): 406–11. doi:10.1006/bbrc.2001.4805. PMID 11327716.
Peri A, Luciani P, Tonacchera M, Agretti P, Baglioni-Peri S, Buci L, Conforti B, Cioppi F, Biliotti G, Serio M, Vitti P, Chiovato L (2002). "Expression of cAMP-responsive element binding protein and inducible cAMP early repressor in hyperfunctioning thyroid adenomas". Eur. J. Endocrinol. 146 (6): 759–66. doi:10.1530/eje.0.1460759. PMID 12039695.
Macho B, Brancorsini S, Fimia GM, Setou M, Hirokawa N, Sassone-Corsi P (2002). "CREM-dependent transcription in male germ cells controlled by a kinesin". Science. 298 (5602): 2388–90. Bibcode:2002Sci...298.2388M. doi:10.1126/science.1077265. PMID 12493914. S2CID 42448155.
Philippar U, Schratt G, Dieterich C, Müller JM, Galgóczy P, Engel FB, Keating MT, Gertler F, Schüle R, Vingron M, Nordheim A (2004). "The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF". Mol. Cell. 16 (6): 867–80. doi:10.1016/j.molcel.2004.11.039. hdl:1721.1/83480. PMID 15610731.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Christensen GL, Wooding SP, Ivanov IP, Atkins JF, Carrell DT (2006). "Sequencing and haplotype analysis of the activator of CREM in the testis (ACT) gene in populations of fertile and infertile males". Mol. Hum. Reprod. 12 (4): 257–62. doi:10.1093/molehr/gal006. PMID 16687568.
Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.