FCGR2C

Protein-coding gene in the species Homo sapiens

FCGR2C

Available structures

PDB

Human UniProt search: PDBe RCSB

List of PDB id codes
3WJL

Identifiers

Aliases

FCGR2C, CD32, CD32C, CDW32, FCG2, FCRIIC, IGFR2, Fc fragment of IgG receptor IIc (gene/pseudogene), FcgammaRIIc, Fc gamma receptor IIc (gene/pseudogene)

External IDs

OMIM: 612169; GeneCards: FCGR2C; OMA:FCGR2C - orthologs

Gene ontology
Molecular function	protein binding IgG binding transmembrane signaling receptor activity
Cellular component	cytoplasm integral component of membrane plasma membrane membrane
Biological process	immune response signal transduction
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


9103


n/a

Ensembl


ENSG00000244682


n/a

UniProt


P31995


n/a

RefSeq (mRNA)


NM_001005410 NM_001005411 NM_001005412 NM_201563


n/a

RefSeq (protein)


NP_963857


n/a

Location (UCSC)

n/a

PubMed search

^[1]

n/a

Wikidata

View/Edit Human

Fc fragment of IgG receptor IIc (gene/pseudogene) is a protein that in humans is encoded by the FCGR2C gene. ^[2]

Function

This gene encodes one of three members of a family of low-affinity immunoglobulin gamma Fc receptors found on the surface of many immune response cells. The encoded protein is a transmembrane glycoprotein and may be involved in phagocytosis and clearing of immune complexes. An allelic polymorphism in this gene results in both coding and non-coding variants.

References

^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Fc fragment of IgG receptor IIc (gene/pseudogene)". Retrieved 2017-05-24.

Breunis WB, van Mirre E, Bruin M, Geissler J, de Boer M, Peters M, Roos D, de Haas M, Koene HR, Kuijpers TW (2008). "Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura". Blood. 111 (3): 1029–38. doi:10.1182/blood-2007-03-079913. PMID 17827395.
Breunis WB, van Mirre E, Geissler J, Laddach N, Wolbink G, van der Schoot E, de Haas M, de Boer M, Roos D, Kuijpers TW (2009). "Copy number variation at the FCGR locus includes FCGR3A, FCGR2C and FCGR3B but not FCGR2A and FCGR2B". Hum. Mutat. 30 (5): E640–50. doi:10.1002/humu.20997. PMID 19309690.
Davila S, Froeling FE, Tan A, Bonnard C, Boland GJ, Snippe H, Hibberd ML, Seielstad M (2010). "New genetic associations detected in a host response study to hepatitis B vaccine". Genes Immun. 11 (3): 232–8. doi:10.1038/gene.2010.1. PMID 20237496.
Chai L, Song YQ, Zee KY, Leung WK (2010). "SNPs of Fc-gamma receptor genes and chronic periodontitis". J. Dent. Res. 89 (7): 705–10. doi:10.1177/0022034510365444. PMID 20439936. S2CID 30256050.
Niederer HA, Willcocks LC, Rayner TF, Yang W, Lau YL, Williams TN, Scott JA, Urban BC, Peshu N, Dunstan SJ, Hien TT, Phu NH, Padyukov L, Gunnarsson I, Svenungsson E, Savage CO, Watts RA, Lyons PA, Clayton DG, Smith KG (2010). "Copy number, linkage disequilibrium and disease association in the FCGR locus". Hum. Mol. Genet. 19 (16): 3282–94. doi:10.1093/hmg/ddq216. PMC 2908468. PMID 20508037.
Pandey JP (2011). "Comments on: Iwasaki et al. Fragment c gamma receptor gene polymorphisms and breast cancer risk in case-control studies in Japanese, Japanese Brazilians, and non-Japanese Brazilians". Breast Cancer Res. Treat. 126 (1): 247–8, author reply 248. doi:10.1007/s10549-010-1233-0. PMID 20978933. S2CID 26361924.
van der Heijden J, Breunis WB, Geissler J, de Boer M, van den Berg TK, Kuijpers TW (2012). "Phenotypic variation in IgG receptors by nonclassical FCGR2C alleles". J. Immunol. 188 (3): 1318–24. doi:10.4049/jimmunol.1003945. PMID 22198951.
Mueller M, Barros P, Witherden AS, Roberts AL, Zhang Z, Schaschl H, Yu CY, Hurles ME, Schaffner C, Floto RA, Game L, Steinberg KM, Wilson RK, Graves TA, Eichler EE, Cook HT, Vyse TJ, Aitman TJ (2013). "Genomic pathology of SLE-associated copy-number variation at the FCGR2C/FCGR3B/FCGR2B locus". Am. J. Hum. Genet. 92 (1): 28–40. doi:10.1016/j.ajhg.2012.11.013. PMC 3542466. PMID 23261299.
Makowsky R, Wiener HW, Ptacek TS, Silva M, Shendre A, Edberg JC, Portman MA, Shrestha S (2013). "FcγR gene copy number in Kawasaki disease and intravenous immunoglobulin treatment response". Pharmacogenet. Genomics. 23 (9): 455–62. doi:10.1097/FPC.0b013e328363686e. PMC 4400828. PMID 23778324.