Protein-coding gene in the species Homo sapiens
EXO5 |
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Identifiers |
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Aliases | EXO5, C1orf176, DEM1, Exo V, hExo5, exonuclease 5 |
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External IDs | MGI: 1920422; HomoloGene: 41497; GeneCards: EXO5; OMA:EXO5 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 1 (human)[1] |
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| Band | 1p34.2 | Start | 40,508,741 bp[1] |
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End | 40,516,038 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 4 (mouse)[2] |
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| Band | 4|4 D2.2 | Start | 120,778,393 bp[2] |
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End | 120,782,214 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - secondary oocyte
- buccal mucosa cell
- tendon of biceps brachii
- testicle
- granulocyte
- ganglionic eminence
- stromal cell of endometrium
- ventricular zone
- islet of Langerhans
- monocyte
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| Top expressed in | - hand
- medial ganglionic eminence
- superior cervical ganglion
- secondary oocyte
- renal corpuscle
- medullary collecting duct
- trigeminal ganglion
- primary oocyte
- otolith organ
- zygote
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - DNA binding
- 4 iron, 4 sulfur cluster binding
- nuclease activity
- iron-sulfur cluster binding
- single-stranded DNA 5'-3' exodeoxyribonuclease activity
- exonuclease activity
- protein homodimerization activity
- hydrolase activity
- single-stranded DNA 3'-5' exodeoxyribonuclease activity
- metal ion binding
| Cellular component | - cytosol
- nucleus
- nucleoplasm
- cytoplasm
| Biological process | - interstrand cross-link repair
- DNA repair
- cellular response to DNA damage stimulus
- nucleic acid phosphodiester bond hydrolysis
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_001346946 NM_001346947 NM_001346948 NM_001346949 NM_001346950
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NM_001346951 NM_001346952 NM_001346953 NM_001346954 NM_001346955 NM_001346956 NM_022774 |
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RefSeq (protein) | NP_001333875 NP_001333876 NP_001333877 NP_001333878 NP_001333879
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NP_001333880 NP_001333881 NP_001333882 NP_001333883 NP_001333884 NP_001333885 NP_073611 |
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Location (UCSC) | Chr 1: 40.51 – 40.52 Mb | Chr 4: 120.78 – 120.78 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Exonuclease 5 is a protein that in humans is encoded by the EXO5 gene. [5]
Function
The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016].
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164002 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028629 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Entrez Gene: Exonuclease 5". Retrieved 2018-04-27.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.