Cicletanine
Chemical compound
- C03BX03 (WHO)
- 3-(4-Chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
- 89943-82-8 Y
- 54910
- 49583 Y
- CHG7QC509W
- D03487 Y
- ChEMBL191886 Y
- DTXSID70868972
- Interactive image
- Clc1ccc(cc1)C3OCc2c3cnc(c2O)C
InChI
- InChI=1S/C14H12ClNO2/c1-8-13(17)12-7-18-14(11(12)6-16-8)9-2-4-10(15)5-3-9/h2-6,14,17H,7H2,1H3 Y
- Key:CVKNDPRBJVBDSS-UHFFFAOYSA-N Y
Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension.[1] The drug is manufactured by Ipsen and marketed by Recordati (in France) under the trade name Tenstaten.
It appears to be more potent in salt-sensitive hypertension.[2]
Mechanism
It can inhibit protein kinase C.[3]
References
- ^ Sassard J (1992). Genetic Hypertension. John Libbey Eurotext. ISBN 978-0-86196-313-3.
- ^ Bagrov AY, Dmitrieva RI, Dorofeeva NA, Fedorova OV, Lopatin DA, Lakatta EG, Droy-Lefaix MT (February 2000). "Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism". Journal of Hypertension. 18 (2): 209–215. doi:10.1097/00004872-200018020-00012. PMID 10694190. S2CID 35374482.
- ^ Fedorova OV, Talan MI, Agalakova NI, Droy-Lefaix MT, Lakatta EG, Bagrov AY (March 2003). "Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension". Hypertension. 41 (3): 505–511. doi:10.1161/01.HYP.0000053446.43894.9F. PMID 12623951.
External links
- Ipsen Corporation
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(and etacrynic acid)
CA inhibitors (at PT) | |
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Loop (Na-K-Cl at AL) | |
Thiazides (Na-Cl at DCT, Calcium-sparing) | |
Thiazide-likes (primarily DCT) |
ESC blockers | |
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Aldosterone antagonists |
(DCT and CD)
- Ethanol, Isopropanol, 2M2B
- mercurial diuretics (Chlormerodrin, Mersalyl, Meralluride)
- Theobromine
- Cicletanine
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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