Cicletanine

Chemical compound
  • C03BX03 (WHO)
Pharmacokinetic dataProtein binding97.3%Elimination half-life7.9 hIdentifiers
  • 3-(4-Chlorophenyl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol
CAS Number
  • 89943-82-8 checkY
PubChem CID
  • 54910
ChemSpider
  • 49583 checkY
UNII
  • CHG7QC509W
KEGG
  • D03487 checkY
ChEMBL
  • ChEMBL191886 checkY
CompTox Dashboard (EPA)
  • DTXSID70868972 Edit this at Wikidata
ECHA InfoCard100.158.583 Edit this at WikidataChemical and physical dataFormulaC14H12ClNO2Molar mass261.71 g·mol−13D model (JSmol)
  • Interactive image
  • Clc1ccc(cc1)C3OCc2c3cnc(c2O)C
InChI
  • InChI=1S/C14H12ClNO2/c1-8-13(17)12-7-18-14(11(12)6-16-8)9-2-4-10(15)5-3-9/h2-6,14,17H,7H2,1H3 checkY
  • Key:CVKNDPRBJVBDSS-UHFFFAOYSA-N checkY
  (verify)

Cicletanine is a furopyridine low-ceiling diuretic drug, usually used in the treatment of hypertension.[1] The drug is manufactured by Ipsen and marketed by Recordati (in France) under the trade name Tenstaten.

It appears to be more potent in salt-sensitive hypertension.[2]

Mechanism

It can inhibit protein kinase C.[3]

References

  1. ^ Sassard J (1992). Genetic Hypertension. John Libbey Eurotext. ISBN 978-0-86196-313-3.
  2. ^ Bagrov AY, Dmitrieva RI, Dorofeeva NA, Fedorova OV, Lopatin DA, Lakatta EG, Droy-Lefaix MT (February 2000). "Cicletanine reverses vasoconstriction induced by the endogenous sodium pump ligand, marinobufagenin, via a protein kinase C dependent mechanism". Journal of Hypertension. 18 (2): 209–215. doi:10.1097/00004872-200018020-00012. PMID 10694190. S2CID 35374482.
  3. ^ Fedorova OV, Talan MI, Agalakova NI, Droy-Lefaix MT, Lakatta EG, Bagrov AY (March 2003). "Myocardial PKC beta2 and the sensitivity of Na/K-ATPase to marinobufagenin are reduced by cicletanine in Dahl hypertension". Hypertension. 41 (3): 505–511. doi:10.1161/01.HYP.0000053446.43894.9F. PMID 12623951.

External links

  • Ipsen Corporation
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Sulfonamides
(and etacrynic acid)
CA inhibitors (at PT)
Loop (Na-K-Cl at AL)
Thiazides (Na-Cl at DCT,
Calcium-sparing)
Thiazide-likes (primarily DCT)
Potassium-sparing (at CD)
ESC blockers
Aldosterone antagonists
Osmotic diuretics (PT, DL)Vasopressin receptor inhibitors
(DCT and CD)OtherCombination products
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